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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BST 6012 APPLICATIONS OF GENOME ENGINEERING IN BIOMEDICINE ELECTIVE 3 0 0 12

Offered By

Biomedicine and Health Technologies

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR ŞERIF ŞENTÜRK

Offered to

Biomedicine and Health Technologies

Course Objective

To gain a thorough understanding of the applications of genome engineering in biomedicine.

Learning Outcomes of the Course Unit

1   to become familiar with applications of genome engineering in biomedicine 2   to discuss the study of health and disease in biomedicine 3   to describe genome engineering tools 4   to describe genome engineering tools in gene therapy 5   to discuss methods of genome engineering applications in diagnosis 6   to discuss methods of genome engineering applications in drug development 7   to discuss methods of genome engineering applications in therapy

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Disease Modelling and Genome Engineering 2 Gene Editing to Create Swine Model in Biomedical Research 3 CRISPR Genome Editing in Mice 4 Engineering Bacteria for Human Health Applications 5 Genome Editing of Pluripotent Stem Cells 6 Application of Genome Engineering in Gene Therapy 7 Gene Editing to Create Agricultural Models 8 Midterm 9 Genome Engineering in Hearing Disorders and Deafness 10 Genome Engineering in Cardiovascular Medicine 11 Genome Engineering for Diabetes 12 Genome Engineering for CNS Diseases 13 Applications of Genome Engineering for Rare Diseases 14 Genome Engineering in Retinal Diseases 15 The Ethics of Human Genome Editing 16 Final Exam

Recomended or Required Reading

Textbook(s): 1. Precision Medicine, CRISPR, and Genome Engineering : Moving from Association to Biology and Therapeutics, Springer 2017 - ISBN: 9783319639031 2. Genome Editing, Springer 2017 ISBN: 9783319341484

Planned Learning Activities and Teaching Methods

Oral presentation, literature search and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40 *** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

Theoretical knowledge will be evaluated by exam

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

serif.senturk@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Preparations before/after weekly lectures 14 8 112 Preparation for final exam 1 15 15 Preparation for midterm exam 1 15 15 Preparing assignments 2 20 40 Preparing assignments 1 20 20 Preparing presentations 2 15 30 Project Preparation 1 20 20 Final 1 5 5 Midterm 1 5 5 TOTAL WORKLOAD (hours) 304

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 5 5 5 5 LO.2 5 5 5 5 5 LO.3 5 5 5 5 5 LO.4 5 5 LO.5 5 5 LO.6 5 5 5 LO.7 5 5 5