COURSE UNIT TITLE

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR GIZEM ÇALIBAŞI KOÇAL

Offered to

Translational Oncology
Translational Oncology

Course Objective

Microbes living in the human body - the human microbiome - can affect the initiation, progression of cancer, and response to treatment, including cancer immunotherapy. The mechanisms of action of the microbiome on cancer may offer advantages for new diagnostic and treatment options, but much is unknown in this respect. Because of the interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself are highly complex, and it cannot explain all of microbiome-based behavior. However, the development of next-generation sequencing technology has allowed the microbiome to be comprehensively studied, allowing the taxonomic and metabolomic relationships between the microbiome and cancer. It has been observed. In addition to being descriptive, these studies also help to reveal the mechanisms of biological processes that affect both the tumor microbiome and the microbiome of other host niches separated from the tumor. With the emergence of biomarker candidates that may be new therapeutic targets as a result of the demonstration of these relationships, trials for therapies that change the microbiome composition of cancer patients have begun to be investigated

Learning Outcomes of the Course Unit

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Recomended or Required Reading

Microbiome and Cancer. 2019. Springer. Editors: Robertson, Erle S.
The Molecular Biology and Translational Medicine. The Microbiome in Health and Disease, Volume 171, 1st Edition. ISBN: 9780128200001. Editor: Jun Sun. 2020. Academic Press.
The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology. Editor(s): Luigi Nibali, Brian Henderson. 2016. Wiley. ISBN:9781118982877
Fulbright LE, Ellermann M, Arthur JC. The microbiome and the hallmarks of cancer. PLoS Pathog. 2017 Sep 21;13(9):e1006480. doi: 10.1371/journal.ppat.1006480. PMID: 28934351; PMCID: PMC5608396.
Intestinal Microbiota in Health and Disease Modern Concepts. Edited By Eduardo J. Schiffrin, Philippe Marteau, Dominique Brassart. ISBN 9781482226768. 2014. CRC Press.
Wong, S.H., Yu, J. Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol 16, 690 704 (2019).
Krautkramer, K.A., Fan, J. & Bäckhed, F. Gut microbial metabolites as multi-kingdom intermediates. Nat Rev Microbiol (2020).
Roy, S., Trinchieri, G. Microbiota: a key orchestrator of cancer therapy. Nat Rev Cancer17, 271 285 (2017)
aniewski, P., Ilhan, Z.E. & Herbst-Kralovetz, M.M. The microbiome and gynaecological cancer development, prevention and therapy. Nat Rev Urol 17, 232 250 (2020).
Liu, NN., Ma, Q., Ge, Y. et al. Microbiome dysbiosis in lung cancer: from composition to therapy. npj Precis. Onc. 4, 33 (2020).
Tran, L., Xiao, JF., Agarwal, N. et al. Advances in bladder cancer biology and therapy. Nat Rev Cancer (2020).

Planned Learning Activities and Teaching Methods

Lectures, the topics with classroom activities (presentations and homework assignments) to consolidate and discussion

Assessment Methods

Further Notes About Assessment Methods

None

Assessment Criteria

1. Defined LO1 and LO2 will be evaluated with mid-term exam.
2. Defined LO3, LO4, LO5, LO6 will be evaluated with homework and presentations prepared by students.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gizem.calibasi@deu.edu.tr ; 0 232 412 58 35

Office Hours

Thursday 14:00-15:00

Work Placement(s)

None

Workload Calculation

Contribution of Learning Outcomes to Programme Outcomes