COURSE UNIT TITLE

: GENERAL BIOCHEMISTRY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TLT 1170 GENERAL BIOCHEMISTRY COMPULSORY 2 0 0 3

Offered By

Medical Laboratory Techniques

Level of Course Unit

Short Cycle Programmes (Associate's Degree)

Course Coordinator

ASSOCIATE PROFESSOR OYA SAYIN

Offered to

Medical Laboratory Techniques

Course Objective

The course aims to provide an advanced understanding of the core principles and topics
of Biochemistry and their experimental basics.
The principal aim of this lecture is to provide knowledge in general biochemistry
sufficient for a medical laboratory technician. Some of the topics covered in the
lecture include information that will ultimately be used in the student s future field.
In order to lead a better understanding of the structures and functions of the
biomolecules, the formation of three-dimensional molecular structures will be studied
in detail. For this purpose, the topics of molecular structure , mole concept and
chemical bonding will be studied comprehensively. In addition apprehension of the
functional groups constituting the biomolecules and their properties will be provided.
A general classification of chemical reactions participated in biochemical processes
will be made along with a discussion about the basic knowledge anticipating their
phyisiological bases (properties of the reaction media, temperature, pH and buffer)
fundemental to their process. Chemical kinetics and catalysis will be studied in order
to make the enzymes which are biological catalysts be understood. Energy is one of the
necessities of life. In order to give a better understanding of this concept, the
functions of chemical thermodynamics such as intrinsic energy , enthalpy ,
entropy , and free energy will be studied and be associated with biological
processes.

Learning Outcomes of the Course Unit

1   Be able to define the principles of basic chemistry that are fundementals of biochemistry
2   Acknowledges the concepts of mol and compound.
3   Comprehends the interaction between matter and light.
4   Be able to explains biochemical concepts in the light of knowledge of basic biochemistry fundementals.
5   Be able to explain general concepts and importance of biochemistry.
6   Comprehends the fundemental concepts that shed light to human biochemistry.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 1. Introduction 1.1. Matter and Energy 1.2. Atom and Mole Concept 1.3. Basic Chemistry Laws
2 2. Water: The Solvent of Life 2.1. Water molecules contain polarized bonds 2.3. pH: Water contains hydronium ions and hydroxyl ions 2.4. Weak acids and weak bases and their pK values
3 3. Covalent Bonds and Noncovalent Interactions 3.1. Bonds are formed by reactions between functional groups 3.2. Isomeric forms are common in biomolecules 3.3. Biomolecules for a variety of noncovalent interactions
4 4. The Major Classes of Biomolecules 4.1. Triglycerides consist of fatty acids and glycerol 4.2. Monosaccharides have either a keto group or an aldehyde group 4.3. Monosaccharide form ring structures 4.4. Complex Carbohydrates are formed by glycosidic bonds 4.5. Polypeptides are formed from amino ac
5 5. Introduction to Protein Structure 5.1. Amino Acids 5.2. Amino Acids are zwitterionic structures 5.3. Amino Acid side chains form many noncovalent interactions
6 6. Protein Structure 6.1. Peptide bonds and disulfide bonds form the primary structure of proteins 6.2. Proteins have complex higher-order structures 6.3. The -helix and ß- pleated sheet are the most common secondary structures in proteins 6.4. Globular proteins have a hydrophobic core
7 7. The Physical Properties of Proteins 7.1. The solubility of proteins depends on pH and salt concentration 7.2. Proteins absorb UV radiation 7.3. Proteins can be separated by their charge or their molecular weight
8 8. their molecular weight 8.1. Oxygen Transporters: Hemoglobin and Myoglobin 8.1. The HEME group is the oxygen-binding site of hemoglobin and myoglobin 8.2. The red blood cells are specialized for oxygen transport 8.3. The hemoglobins are tetrameric proteins 8.4. Methemoglobin is a nonfunctional, oxidized form of hemoglobin
9 9. Enzymatic Reactions 9.1. Thermodynamics 9.2. The free energy change is the driving force for chemical reactions 9.3. The standard free energy change is related to the equilibrium constant 9.4. Enzyme Kinetics 9.5. Enzymes decrease the free energy of activation 9.6. Many enzymatic reactions can be
10 10. Coenzymes 10.1. ATP has two energy-rich bonds 10.2. ATP is the phosphate donor in phosphorilation reactions 10.3. ATP hydrolysis can be coupled to endergonic reactions 10.4. Some coenzymes participate in dehydrogenase
11 11. Carbohydrates 11.1. Generale Structure of the carbohydrates 11.2. Glucose is the principal transported carbohydrate in humans 11.3. Glycogen is synthesized from glucose 11.4. Fructose and galactose
12 12. Fatty Acids and Triglycerides 12.1. The Generation of Metabolic Energy from Fatty Acids 12.2. Membrane Lipids 12.3. Cholesterol is the least-soluble membrane lipid 12.4. Lipoproteins

Recomended or Required Reading

To be announced.

Planned Learning Activities and Teaching Methods

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ODV PerfÖdev
2 FN Final
3 BSN FinSonuBşrNotu ODV * 0.50 + FN * 0.50
4 BUT Bütünleme Notu
5 BBN Bütünleme Sonu Başarı Notu ODV * 0.50 + BUT * 0.50


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

To be announced.

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
TOTAL WORKLOAD (hours) 0

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14PO.15PO.16PO.17PO.18
LO.155555
LO.255
LO.355
LO.4555
LO.5555
LO.6555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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