COURSE UNIT TITLE

: OXIDATIVE STRESS, FREE RADICALS AND ANTIOXIDANT DEFENSE

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MOT 6033 OXIDATIVE STRESS, FREE RADICALS AND ANTIOXIDANT DEFENSE ELECTIVE 2 2 0 9

Offered By

Molecular Medicine

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR ZAHIDE ÇAVDAR

Offered to

Molecular Medicine
Molecular Medicine

Course Objective

The purpose of this course is to learn types and formation of free radicals and also damages on biomolecules resulted from free radicals. In parallel, it involves the antioxidant defense system. The role of oxidative stress in the formation of various disease will be discussed. In the practise session of this course, techniques using in the detection of oxidant and antioxidant parameters will be performed in the laboratory.

Learning Outcomes of the Course Unit

1   Define the term free radical and explain the types and sources of free radical .
2   Describe the oxidative stress and its damages on biomolecules
3   Learn the oxidative stress induced by metals.
4   Classify the antioxidants and explain the mechanism of antioxidants.
5   Know the techniques using for detection of oxidant and antioxidant parameters.
6   Understant the mechanism of various disease related to oxidative stres.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Free radicals, The effects of free radicals on biomolecules, Antioxidant defense system, Techniques using for monitoring of oxidant parameters
2 Techniques using for monitoring of antioxidant parameters
3 Discussion of articles related to disease associated with oxidative stres

Recomended or Required Reading

1. Harper s Illustrated Biochemistry. Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW. McGrawHill Lange, 28 th edition, 2009.
2. Newsholme, EA and Leech, TR. Functional Biochemistry in Health and Disease 2010, WILEY-BLACKWELL, Oxford.
3. Reviews related to topics

Planned Learning Activities and Teaching Methods

The course will be run in an integrated way-winding theory with case discussion and laboratory practicals. The methods of learning will be interactive.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.30 + FIN* 0.50
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.30 +RST* 0.50


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

If needed, other assessment methods can be added to the table given below.

Language of Instruction

Turkish

Course Policies and Rules

The student is expected to read the resources before coming to class.

Contact Details for the Lecturer(s)

Assist Prof.Dr. Zahide Çavdar
Phone: 412 2617

Office Hours

Tuesdays 13.00-14.00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 2 30
Tutorials 30 2 60
Preparations before/after weekly lectures 15 2 30
Preparing assignments 1 15 15
Preparing presentations 1 20 20
Midterm 1 25 25
Final 1 45 45
TOTAL WORKLOAD (hours) 225

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14
LO.155435434533333
LO.254435434533333
LO.355435434533333
LO.455435434533333
LO.555555434533333
LO.655435434533553

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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