Dokuz Eylül University Information Package / Courses Catalog

Description of Individual Course Units

Course Unit Code	Course Unit Title	Type Of Course	D	U	L	ECTS
ONK 6072	THE SIGNAL TRANSDUCTION MECHANISMS OF CANCER CELLS	ELECTIVE	1	0	0	3

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology
Adeloscent and Young Adult Oncology PhD

Course Objective

Define and understanding of the molecular biology of cancer, signal transduction, receptors and ligands engaged by the issue of concepts and their reflection of the clinic. Define and understanding of the changes in cell division and signaling mechanisms in cancer, cancer, and molecular targets of signal transduction systems, control of the transcriptional regulators, and the signal of a transduction mechanism of clinically relevant cancers, particularly lung cancer.

Learning Outcomes of the Course Unit

1	Capable of express in general terms of signal transmission mechanisms in the context of the molecular biology of cancer.
2	Be able to recognize and understand the cancer signal transduction systems and molecular targets, molecular mechanisms of control of transcriptional regulators.
3	Knows signal mechanisms of clinically relevant cancers with examples of specific types of cancer
4	Understands changes in signaling in cell division and the life of cancer cells.
5	Be able to criticize and plan the signal transduction mechanisms of cancer cells

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week	Subject	Description
1	The overview of signaling of cancer cells
2	Differences from normal cell to cancer cell signaling
3	Ligands and receptors in cancer cell signaling
4	Transduction of signaling to the cancer cell (protein kinases, protein phosphatase, lipid kinases, lipid phosphatase, phospholipases, nucleotide cyclases, GTPs, ..)
5	Multiprotein signaling complexes formation (domains and motifs)
6	Control in transduction of signaling and protein level (Regulation of Protein Levels: Transcription, Translation, and Proteolysis)
7	Changes in cell cycle and life of cancer cells- I
8	Changes in cell cycle and life of cancer cells- II
9	Changes in cell cycle and life of cancer cells- III
10	Systems of cancer signaling and molecular targets
11	Control of cancer signal transduction and transcriptional regulators
12	Signal transduction and transcription factors in Lung Cancer
13	Signal transduction and transcription factors in Breast Cancer
14	Signal transduction and transcription factors in Colon Cancer
15	Signal transduction and transcription factors in Prostate Cancer
16	Final Exam

Recomended or Required Reading

1. Textbook(s): Diagnostic Approach to Clinical Oncology Mario W. Fiorentino PICCIN 1999
2. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
3. AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
4. Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
5. Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
6. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
7. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007
8. Molecular biology of the gene Watson JD, et al. 2004 Fifth edition .
9. Cancer Principles and Practice of Oncology Devita VT, Lawrence TS, Rosenberg SA, Wolters Kluwer& Lippincott Willams & Wilkins 2008 Eighth Edition

Planned Learning Activities and Teaching Methods

Theoretical and practical courses done, discussed the importance of signaling pathways in the particular type of cancer, properties of and importance of signaling pathways in at given assignment and final exam done.

Assessment Methods

SORTING NUMBER	SHORT CODE	LONG CODE	FORMULA
1	ASG	ASSIGNMENT
2	SEM	SEMINAR
3	FCG	FINAL COURSE GRADE	ASG * 0.40 + SEM * 0.60

*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

1.Being able to express in general terms the signal transduction mechanisms in molecular biology of cancer , prepared homework related to a features and importance of particular type of cancer signaling pathway will be assessed.
2. To question the making of intermediate and searching capabilities related to molecular biology of cancer signaling researches will be evaluate with final exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Zekiye Altun
zekiye.altun@deu.edu.tr 0 232 4125871/5801

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities	Number	Time (hours)	Total Work Load (hours)
Lectures	15	1	15
Preparation for final exam	1	36	36
Preparing assignments	1	21	21
Final	1	3	3
TOTAL WORKLOAD (hours)			75

Contribution of Learning Outcomes to Programme Outcomes

PO/LO	PO.2	PO.3	PO.4	PO.5	PO.6	PO.7	PO.8	PO.9	PO.10	PO.11
LO.1		5	5			5		5	5	5
LO.2	5	5	5	5	5	5	5	5	5	5
LO.3	5	5	5	5		5	5	5	5	5
LO.4	5	5	5	5	5	5	5			5
LO.5	5	5	5	5	5	5	5			5

COURSE UNIT TITLE

DEGREE PROGRAMMES

Description of Individual Course Units

Offered By

Level of Course Unit

Course Coordinator

Offered to

Course Objective

Learning Outcomes of the Course Unit

Mode of Delivery

Prerequisites and Co-requisites

Recomended Optional Programme Components

Course Contents

Recomended or Required Reading

Planned Learning Activities and Teaching Methods

Assessment Methods

Further Notes About Assessment Methods

Assessment Criteria

Language of Instruction

Course Policies and Rules

Contact Details for the Lecturer(s)

Office Hours

Work Placement(s)

Workload Calculation

Contribution of Learning Outcomes to Programme Outcomes

CONTACT INFORMATION