COURSE UNIT TITLE

: EPIGENETIC

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TBG 6113 EPIGENETIC ELECTIVE 3 0 0 10

Offered By

Medical Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR HAKKI OGÜN SERCAN

Offered to

Medical Biology and Genetics

Course Objective

In depth lecture and literature-based assessment of epigenetic mechanisms of mammalian gene regulation. Particular emphasis will be placed on how loss of proper epigenetic control leads to human disease and how novel therapies might correct epigenetic defects

Learning Outcomes of the Course Unit

1   Explains epigenetic mechanisms
2   Discusses chromatin Modifications and their Mechanisms
3   Compares and evaluates the latest methodologies in the fields epigenetics field
4   Evaluates and draws conclusions on epigenetic mechanisms that play a role in the development of neurodegenerative diseases
5   Explains roles of Epigenetic Reprogramming, and DNA Methylation in Mammalian Development and Cancer
6   Discusses roles of Epigenetic Reprogramming, and DNA Methylation in the development of Neurodegenerative diseases
7   Understands the role of epigenetic mechanisms in ageing

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction: a-Overview and concepts b- History of Epigenetics
2 Epigenetic Mechanisms of Gene Regulation: Basic mechanisms, de novo DNA methylation and the genome, DNA methyltransferases and their connections to chromatin, methyl binding proteins and their connections to chromatin methylation as a genome defense system, Chromatin Modifications and their Mechanisms in Action
3 Histone Modifications and Bivalent Histones: Regulation of chromatin structure by site-specific histone methyltransferases
4 Polycomb and Trithorax and RNA-directed Silencing: Polycomb-Group Silencing Mechanisms, Polycomb complexes and epigenetic states,Regulation of heterochromatic silencing by RNAi
5 Epigenetic Reprogramming, and the Role of epigenetic modifications in Mammalian Development
6 The effects of microenvironment on epigenetics modifications
7 Dec Exam
8 Epigenetic Reprogramming, and its Role in Mammalian Development
9 Epigenetic modifications and diseases 1 (Neurodegenerative diseases)
10 Epigenetic modifications and diseases 2 (Cancer)
11 Epigenetic modifications and diseases 3 (Ageing)
12 Epigenetics, Embryonic Stem Cells, IPSC, Pluripotency, and Differentiation: Epigenetic mechanisms regulating ES cell differentiation down certain lineages and in maintaining pluripotency Nuclear transplantation and the reprogramming, IPSC
13 Methods in Epigenetics 1: Methods for the analysis of DNA methylation patterns (Highthroughput technologies, genomewide DNA methylation profiling) chromatin structure
14 Methods in Epigenetics 2: Methods for the analysis of histone modification patterns.
15 Computational Epigenetics: Databases, Exploratory analysis and Analysing multivariate genomic data, DNA methylation prediction, prediction of imprinted genes

Recomended or Required Reading

To be announced.

Planned Learning Activities and Teaching Methods

Oral Presentation: Basic information, especially the subjects that are hard to understand or unreachable will be given by tutor.
Article Discussion: Some up to date articles related to the basic subjects will be chosen and students will be asked to read and discuss.
Home Work: Several questions aiming to increase the synthesis and analysis abilities of students will be given and asked for a written report.
Case Discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.30 + FIN* 0.50
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.30 +RST* 0.50


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

Written Exams: At least 75% of questions should be answered correctly.
Oral presentation (20%): A selected published paper will be presented in the class. The presenter will introduce the background and rationale for the study, explain the supporting data, and summarize the major findings of the paper. The presenter is also encouraged to critique the paper, pointing out it s strengths and weaknesses.
Assay (20%): The presenter will be expected to prepare a critique pointing out the strengths and weaknesses of the paper.
Group discussion (20%): Students will be expected to contribute to the discussion and critique of the paper being presented in the class. (Reading the papers before the presentation is absolutely mandatory. At the beginning of each meeting, you must hand in a form on which you will provide a synopsis of the paper, and a brief statement on which experiments you think would be the next logical step to take. This must be done before the class meets.)

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Contact Details for the Instructor:
Tlf: 232 4601 or 4600 or 4609
nese.atabey@deu.edu.tr
esra.erdal@deu.edu.tr

Office Hours

From Monday to Friday at 12:00-13:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 2 30
Preparations before/after weekly lectures 15 3 45
Preparation for midterm exam 1 6 6
Preparation for final exam 1 10 10
Preparation for quiz etc. 2 3 6
Preparing Individual Assignments 5 10 50
Preparing Group Assignments 5 10 50
Preparing Presentations 5 10 50
Final 1 3 3
Midterm 1 3 3
Quiz etc. 2 3 6
TOTAL WORKLOAD (hours) 259

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9
LO.12345
LO.22345
LO.3345
LO.412345
LO.512345
LO.62345
LO.712345