COURSE UNIT TITLE

: FREE RADICALS IN BIOCHEMISTRY

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
KIM 5119 FREE RADICALS IN BIOCHEMISTRY ELECTIVE 3 0 0 7

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSISTANT PROFESSOR KEVSER KUŞAT

Offered to

M.Sc. in Biochemistry
Chemistry
Chemistry
Ph.D in Biochemistry

Course Objective

Biochemically elucidation of radical effects on metabolism and the diseases related with antioxidant defense systems utilised for removing the effects of radicals, mechanisms and radical interactions will be discussed by studying generation mechanisms of radicals which are of significance for metabolism.

Learning Outcomes of the Course Unit

1   Have a knowledge about the formation mechanisms of radicals,
2   Discuss the positive and negative effects of radicals on functioning of the metabolism,
3   Have a knowledge about and discuss the defense systems which eliminate negative effects of radicals and their mechanisms,
4   Discuss repair mechanisms of damaged molecules by radicals,
5   Aware of the importance of antioxidants in ageing and struggling with diseases.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 General Overview to Oxygen Toxicity and Reactive Oxygen Species
2 The Chemistry of Free Radicals and Related Reactive Species 1: Chemistry of Biologically Important Radicals
3 The Chemistry of Free Radicals and related Reactive Species 2: Chemistry of Biologically Important Non-radicals
4 Antioxidant Defenses
5 Oxidative Stress: Adaptation, Damage, Repair and Death
6 Cellular Targets of Oxidative Stress 1: DNA
7 Cellular Targets of Oxidative Stress 2: Lipid
8 Midterm Exam
9 Cellular Targets of Oxidative Stress 3: Protein
10 The Repair Mechanism of DNA, Lipid and Protein Damages
11 Free Radicals and Toxicology
12 The Relation of Free Radicals with Diseases 1: Atherosclerosis, Hypertension, Diabetes, Ischaemia-Reperfusion
13 The Relation of Free Radicals with Diseases 2: Cancer, Alzheimer s Disease
14 The Roles of Antioxidants in Ageing, Nutrition, Diseases and Their Treatments; Presentations

Recomended or Required Reading

Textbook(s): Halliwell B. Gutteridge M. C. J., Free Radicals in Biology and Medicine, Oxford University press, 1998.
Supplementary Book(s): Rice-Evans C., Burdon R.H., Free Radical Damage and Its Control, Elsevier Science B.V., 1994.

Planned Learning Activities and Teaching Methods

1. Presentation
2. Interactive narrative
3. Question-answer technique
4. Homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCG FINAL COURSE GRADE
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT)


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

Meaningful learning of the basic concepts given in presentations, association of concepts with each other, establishing the cause-result relationships and making comments by using the information available for problems and evaluating idea generation are carried out with mid-term, final and resit exams, active participation to the lecture, homework.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Dokuz Eylul University, Faculty of Science, Department of Chemistry
e-mail: leman.tarhan@deu.edu.tr

Office Hours

Wednesday 13.30-15.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 3 39
Preparations before/after weekly lectures 13 3 39
Preparation for midterm exam 1 10 10
Preparation for final exam 1 20 20
Preparing assignments 2 15 30
Preparing presentations 2 15 30
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 172

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.15555555
LO.255555555
LO.35555555
LO.45555555
LO.555555555