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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BYL 5076 EPIGENETICS ELECTIVE 3 0 0 6

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSISTANT PROFESSOR ASLI SADE MEMIŞOĞLU

Offered to

Biology

Course Objective

To understand what epigenetic is and its mechanisms and follow developments in the field.

Learning Outcomes of the Course Unit

1   Understand epigenetics 2   Understand epigenetic regulatory mechanisms 3   Understand the importance of epigenetic regulations in biological processes 4   Have information on the epigenetic research methods 5   Follow and comment on hte current epigenetic research

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Transgenerational effects, twins and development as epigenetic processes 2 Introduction to histones, chromatin packing, transcription factors and gene expression First paper assignment 3 DNA methylation, histone modifications, and epigenetic regulators 4 The epigenetic code for gene silencing 5 The epigenetic code for gene activation and long-distance regulation 6 PcG proteins and RNA-mediated heterochromatin formation Paper discussion 7 Imprinting 8 Midterm 9 X-inactivation Second paper assignment 10 Development revisited: reprogramming in PGCs and TrXs 11 iPS cells and Ageing 12 Cancer epigenetics Paper discussion 13 Neuroepigenetics 14 Final exam

Recomended or Required Reading

Epigenetics, second edition.2015. C. David Allis, Marie-Laure Caparros, Thomas Jenuwein, Danny Reinberg. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY. The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance.2012. Nessa Carey. London: Icon Books Ltd. Articles to be assigned during the course

Planned Learning Activities and Teaching Methods

The course will consist of lectures, paper discussions, presentations, question and answers

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40 *** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

Research paper discussions during the semestre, mid-term and final exam

Language of Instruction

Turkish

Course Policies and Rules

The students have to continue to the class as 70% in a term

Contact Details for the Lecturer(s)

asli.memisoglu@deu.edu.tr

Office Hours

To be announced

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 12 3 36 Preparations before/after weekly lectures 10 8 80 Preparation for midterm exam 1 15 15 Preparation for final exam 1 15 15 Final 1 2 2 Midterm 1 2 2 TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 PO.9 PO.10 PO.11 PO.12 LO.1 3 2 5 1 3 2 2 2 2 1 2 3 LO.2 4 2 5 1 4 2 2 3 4 2 3 4 LO.3 5 4 5 1 5 2 3 4 4 4 3 2 LO.4 5 5 5 1 5 5 5 5 5 5 2 1 LO.5 5 5 5 1 5 5 5 5 5 5 2 1