COURSE UNIT TITLE

: GENOME EDITING TECHNOLOGIES

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MBG 6111 GENOME EDITING TECHNOLOGIES ELECTIVE 3 0 0 12

Offered By

Molecular Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR ŞERIF ŞENTÜRK

Offered to

Molecular Biology and Genetics
Biomedicine and Health Technologies
Molecular Biology and Genetics

Course Objective

This course aims to discuss the recent developments on and the applications of genome editing technologies. The participants will understand the potential uses of such technologies in medicine, biology and biotechnology, especially in the context of gene therapy, drug discovery and development, gene regulation and agricultural yield and quality.

Learning Outcomes of the Course Unit

1   To understand the basis of genome editing technology.
2   To explain the different tools in genome editing.
3   To know the potential uses of genome editing in biology and biotechnology.
4   To understand the basis of drug discovery and gene therapy approaches.
5   To understand the basics of CRISPR-Cas9 based drug discovery tools.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Genome editing approaches
2 Site specific nucleases
3 Paper Discussions 1 - Zinc Finger Nucleases
4 Paper Discussions 2 - TALENs
5 CRISPR-Cas9-based editing
6 Paper Discussions 3 - CRISPR-Cas off-targets and solutions
7 Midterm exam
8 Guide RNA Prediction and design
9 Paper Discussions 4 - CRISPR-Cas9 in Genome-wide screens
10 Transgenic animal models
11 Paper Discussions 5 - CRISPR-Cas in drug target discovery
12 Applications in medicine and biotechnology
13 Paper Discussions 6 - CRISPR-Cas in gene therapy
14 Paper Discussions 7 - CRISPR-Cas in agriculture (crop yield)
15 Class discussion on ethical issues
16 Final exam

Recomended or Required Reading

Textbook(s): Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery
Cambridge University Press, ISBN 978-4-431-55227-7 (Print) 978-1-316-75630-0 (Online)
Supplementary Book(s): Editing Mankind, Humanity in the Age of CRISPR and Gene Editing, Pegasus Books
ISBN: 978-1-643-13308-9
References: The CRISPR Journal, ISSN: 2573-1599 | Online ISSN: 2573-1602

Planned Learning Activities and Teaching Methods

1- Taught in lectures
2- Student presentations
2- Questions and answers
3- Discussion
4- Homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 MTE MIDTERM EXAM
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None.

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

serif.senturk@deu.edu.tr
0 (232) 412 6514

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 3 42
Preparations before/after weekly lectures 14 6 84
Preparation for midterm exam 1 30 30
Preparation for final exam 1 37 37
Preparing assignments 12 5 60
Preparing presentations 2 20 40
Final 1 3 3
Midterm 1 4 4
TOTAL WORKLOAD (hours) 300

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8
LO.13
LO.22
LO.32
LO.42
LO.52

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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