COURSE UNIT TITLE

: DNA DAMAGE, DNA REPAIR AND RELATED DISEASES

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MOT 6021 DNA DAMAGE, DNA REPAIR AND RELATED DISEASES ELECTIVE 1 0 0 3

Offered By

Molecular Medicine

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR GÜL HÜRAY IŞLEKEL

Offered to

Molecular Medicine
Molecular Medicine

Course Objective

The aim of this course is to allow the students to learn the basic knowledge about oxidative DNA damage and repair mechanism and related research techniques.

Learning Outcomes of the Course Unit

1   To know about the different DNA damage products
2   To know about the different DNA damage products
3   To learn about the different DNA repair proteins
4   To address different aspects of knowledge in the field of DNA base damage
5   To understand the basic principles of techniques used for DNA damage products
6   To understand the basic principles of techniques used for DNA repair proteins

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Oxidative Stres and free radicals
2 Oxidative Stres and free radicals
3 Oxidative DNA damage
4 Oxidative DNA damage
5 Oxidative DNA damage and repair
6 Oxidative DNA damage and repair
7 Oxidative DNA damage and repair
8 Biological response to DNA damage
9 DNA Repair
10 Proteomics and DNA Repair
11 Oxidative DNA Damage and biological consequences
12 Oxidative DNA Damage and diseases
13 Oxidative DNA Damage and diseases
14 Oxidative DNA Damage and diseases
15 FINAL

Recomended or Required Reading

1. Free-Radical-Induced DNA Damage and Its Repair, Clemens Von Sonntag, Springer-Verlag Berlin Heidelberg 2006
2. Free Radicals in Biology and Medicine, BarryHalliwell and John M. C. Gutteridge Fourth Edition Oxford University Press, Oxford, 2007
3. DNA Repair and mutagenesis, Errol C. Friedberg, Graham C. Walker, Wolfram Siede,Richard D. Wood, Roger A.Schultz and Tom Ellenberger Second Edition ASM Press, Washington DC, 2006
4. Mass Spectrometry, Edmond deHoffmann and Vincent Stroobant Second Edition John Wiley, Chichester, 2002

Planned Learning Activities and Teaching Methods

The course will be organised as theoretical courses and rotations in different labs.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 LAB LABORATORY
4 FIN FINAL EXAM
5 FCGR FINAL COURSE GRADE MTE * 0.20 + ASG * 0.10 + LAB* 0.20 + FIN*0.50
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.20 + ASG * 0.10 + LAB* 0.20 + RST*0.50


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

The student is expected to read the resources before coming to class. In addition, he/she is expected to contribute actively to discussion.

Contact Details for the Lecturer(s)

Prof Dr. Hüray Işlekel
Phone: 412 44 08

Office Hours

Tuesday: 12.30-13:30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 1 14
Preparations before/after weekly lectures 14 2 28
Preparation for final exam 1 20 20
Preparing presentations 1 10 10
Final 1 3 3
TOTAL WORKLOAD (hours) 75

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14
LO.155335534333224
LO.255335534333224
LO.355335534333224
LO.455335534333224
LO.555555534333555
LO.655555533453555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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