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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BST 5013 GENE AND CELL THERAPY ELECTIVE 3 0 0 9

Offered By

Biomedicine and Health Technologies

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSISTANT PROFESSOR YAVUZ OKTAY

Offered to

Biomedicine and Health Technologies

Course Objective

To provide a comprehensive review of current methods in gene therapy and their applications in medicine.

Learning Outcomes of the Course Unit

1   to become familiar with the history of gene therapy. 2   to discuss the opportunities and pitfalls of gene and cell therapy. 3   to gain a thorough understanding of gene and cell therapy methods. 4   to become familiar with applications of gene and cell therapy for various disease groups. 5   to learn how to conduct scientific research and present findings.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Week 1 History of gene and cell therapy 2 Week 2 Retroviral vectors 3 Week 3 Adeno-associated vectors 4 Week 4 Viral- and Non-viral-Based Hybrid Vectors 5 Week 5 Pharmaco-gene therapy 6 Week 6 Aptamers 7 Week 7 Gene-modified cell therapies 8 Week 8 MIDTERM 9 Week 9 Stem Cells as Therapeutics in Retinal Degenerative Diseases 10 Week 10 CAR-T cells 11 Week 11 Genome engineering with CRISPR/Cas9 tools 12 Week 12 Gene therapy for Neurological Disorders 13 Week 13 Gene therapy for Metabolic Disorders 14 Week 14 Gene therapy of Solid Cancers 15 Week 15 Assignment Presentations 16 Week 16 FINAL EXAM

Recomended or Required Reading

Suggested Textbook(s): Gene and Cell Therapy: Biology and Applications, by Giridhara R. Jayandharan (ed.). Springer-Nature Singapore, 2018 ISBN: 978-981-13-0480-4

Planned Learning Activities and Teaching Methods

Oral presentation, literature search and discussion.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40 *** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Yavuz.oktay@deu.edu.tr

Office Hours

Wednesday 14:00-15:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Preparations before/after weekly lectures 14 6 84 Preparation for midterm exam 1 15 15 Preparation for final exam 1 20 20 Preparing assignments 1 50 50 Preparing presentations 1 15 15 Midterm 1 3 3 Final 1 3 3 TOTAL WORKLOAD (hours) 232

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 5 5 5 LO.2 5 5 LO.3 5 5 5 LO.4 5 5 5 LO.5 5 5 5