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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BST 5012 GENE EDITING TECHNOLOGIES ELECTIVE 3 0 0 9

Offered By

Biomedicine and Health Technologies

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSOCIATE PROFESSOR ŞERIF ŞENTÜRK

Offered to

Biomedicine and Health Technologies

Course Objective

To provide a comprehensive understanding of gene editing technologies.

Learning Outcomes of the Course Unit

1   to become familiar with gene editing technologies 2   to discuss the history of gene editing technologies 3   to provide an introduction to gene editing 4   to describe TALENs, ZFNs and CRISPR 5   to discuss methods of gene editing in disease modelling 6   to describe applications of gene editing in biomedicine 7   to describe regulations on gene editing

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Introduction to Genome Engineering 2 History of Genome Engineering 3 An Overview of Gene Editing Tools 4 Gene Editing by Zinc Finger Nucleases 5 Gene Editing by TALENs 6 Gene Editing by CRISPR-Cas9 System 7 Applications of ZFNs 8 Applications of TALENs 9 Applications of CRISPR-Cas9 System 10 Genome Editing in Human Cells 11 Genome Editing in Embryos 12 Genome Engineering in Plants 13 Genome Engineering in Animals 14 Application of Gene Editing in biomedicine 15 Ethical and Regulatory Issues on Genome Engineering

Recomended or Required Reading

Suggested Textbook(s): Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery, Edited by Krishnarao Appasani Cambridge University Press, 2018 ISBN: 9781316756300 Additional Materials: CRISPR 101: A Desktop Resource. Created and Compiled by Addgene May 2017 (2nd Edition)

Planned Learning Activities and Teaching Methods

Oral presentations, literature search and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40 *** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

Theoretical knowledge will be evaluated by exam.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

serif.senturk@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Preparations before/after weekly lectures 14 6 84 Preparation for midterm exam 1 15 15 Preparation for final exam 1 15 15 Preparing assignments 1 30 30 Preparing presentations 1 10 10 Preparing assignments 1 20 20 Midterm 1 5 5 Final 1 5 5 TOTAL WORKLOAD (hours) 226

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 5 5 5 5 LO.2 5 5 5 LO.3 5 5 5 5 5 LO.4 5 5 5 5 5 LO.5 5 5 5 5 LO.6 5 5 5 5 LO.7 5 5 5