COURSE UNIT TITLE

: CANCER TECHNOLOGIES AND DRUG DEVELOPMENT

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 6005 CANCER TECHNOLOGIES AND DRUG DEVELOPMENT ELECTIVE 1 0 0 6

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR YASEMIN BAŞBINAR

Offered to

Translational Oncology
Translational Oncology

Course Objective

Course Objective: fundamental and emerging technologies which is used in preclinical and clinical cancer research will be discussed.
Cancer biomarker technologies, in vivo imaging technologies, drug development technologies, immune modulation technologies, stem cell technology, recombinant protein technology, sampling in clinical research, microfluidic systems in cancer research, bioinformatics and modeling technologies, new molecular drug target characterization, validation of the targets, targeted drugs in clinical trials will be explained.

Learning Outcomes of the Course Unit

1   1. Knowledgeable about biomarkers in cancer research.
2   2. Be able to know the sampling in cancer research
3   3. Be able to know drug development, in vivo imaging and recombinant protein technologies.
4   4. Acquire knowledge of bioinformatics and modeling technologies in cancer research
5   5. Be able to expresse to the concept of targeted drug development
6   6. Be able to critically evaluate the published literature in the field of the drug development

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 The drug discovery and development process
2 Classical targets in drug discovery (Protein structure, enzyme, ion channels, membrane transport proteins)
3 Target selection and identification of a clinical candidate
4 In vitro drug screening
5 In vitro ADME and In vivo pharmacokinetics
6 Cellular and biological product technologies
7 Microfluidic technologies
8 Animal models and in vivo studies
9 Cancer diagnosis and imaging technologies
10 Basics and phases clinical trials (Phase I-II-III-IV)
11 Designing clinical trials
12 In silico technologies
13 Translational oncology and biomarkers
14 Intellectual property and patents in drug discovery
15 Drug production technologies

Recomended or Required Reading

Turner, J. Rick. New Drug Development. An Introduction to Clinical Trials: Second Edition. 2010. Springer
Poduri, Ramarao. Drug Discovery and Development: From Targets and Molecules to Medicines. 2021. Springer
Benjamin Blass. Basic Principles of Drug Discovery and Development. 1st Edition. 2015. Academic Press
Ahlbrandt J, Lablans M, Glocker K, Stahl-Toyota S, Maier-Hein K, Maier-Hein L, Ückert F. Modern Information Technology for Cancer Research: What's in IT for Me An Overview of Technologies and Approaches. Oncology. 2020;98(6):363-369. doi: 10.1159/000493638. Epub 2018 Nov 15. PMID: 30439700.
Molecular Biology of the Cell, 6th Edition. Ed. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishers
Essential Cell Biology - 4th Edition Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter Garland Publishers
The Biology of Cancer, 2nd Edition, Robert A. Weinberg, Garland Publishers
Molecular Biology of the Gene, 7th edition, James Watson, Alexander Gann, Tania Baker, Michael Levine, Stephan Bell, Richard Losick, Stephan Harrison Pearson Cold Spring harbor Laboratory Press.
Principles of Molecular Diagnostics and Personalized Cancer Medicine, Dongfeng Tan, henry Lynch, Wolters Kluwer, Lippincott Williams&Wilkins.
The Handbook of Biomarkers, Kewal Jain, Humana Press
Translational and Experimental Clinical Research, Daniel Schuster, William Powers, Lippincott Williams&Wilkins

Planned Learning Activities and Teaching Methods

Lectures, the topics with classroom activities (presentations and homework assignments) to consolidate and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 + FIN* 0.60
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 +RST* 0.60


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

1. The learner will clearly define outlined LO1, LO3, LO5, and which will evaluate with exam.
2. The learner will recognize LO2, LO4, LO6 will evaluate with homework, prepared presentations by themselves and exam

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

e-mail: yasemin.baskin@deu.edu.tr ; 0 232 412 8231

Office Hours

Thursday 11:00-12:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparations before/after weekly lectures 15 5 75
Preparation for midterm exam 1 8 8
Preparation for final exam 1 10 10
Preparing assignments 5 4 20
Preparing presentations 2 10 20
Final 1 1 1
Midterm 1 1 1
TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.15555555
LO.25555555
LO.355555555
LO.4555555555
LO.5555555555
LO.655555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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