COURSE UNIT TITLE

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR GIZEM ÇALIBAŞI KOÇAL

Offered to

Translational Oncology
Translational Oncology

Course Objective

Tumour micro-environment is a target for new therapeutic strategies which plays an important role in the processes of tumour formation, growth and metastasis. In this context, hypoxia and cancer, tumour angiogenesis, tumour immune system relationships, inflammation and cancer, tumour-stroma relationship, extracellular matrix , micro-environmental effects in invasion and metastasis, cancer stem cell and mesenchymal stem cell relationships, tumour growth and microenvironment, The role of the microenvironment in drug resistant, microenvironment as a new therapeutic targets will be discussed.

Learning Outcomes of the Course Unit

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Recomended or Required Reading

Tumor Microenvironment. Editor(s): Dietmar W. Siemann. 2011. Wiley. Print ISBN:9780470749968. Online ISBN:9780470669891. DOI:10.1002/9780470669891
The Tumor Microenvironment. 2010. Springer. Editors: Bagley, Rebecca G. (Ed.)
Tumor Microenvironment - The Main Driver of Metabolic Adaptation. Editor Jacinta Serpa. 2020. Springer.
Tumor Microenvironment. Editor(s): Chmielik, Ewa (Gliwice). 2020. Karger. ISBN: 978-3-318-06777-4. DOI: 10.1159/isbn.978-3-318-06778-1
Petrova, V., Annicchiarico-Petruzzelli, M., Melino, G. et al. The hypoxic tumour microenvironment. Oncogenesis 7, 10 (2018).
Ngiow SF, Young A. Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies.Front Immunol. 2020 Jul 28;11:1633. doi: 10.3389/fimmu.2020.01633. PMID: 32849557; PMCID: PMC7399169.
Joyce JA. Therapeutic targeting of the tumor microenvironment. Cancer Cell. 2005 Jun;7(6):513-20. doi: 10.1016/j.ccr.2005.05.024. PMID: 15950901.
Stylianopoulos T, Munn LL, Jain RK. Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. Trends Cancer. 2018 Apr;4(4):292-319.doi: 10.1016/j.trecan.2018.02.005. Epub 2018 Mar 13. PMID: 29606314; PMCID: PMC5930008.
Emon B, Bauer J, Jain Y, Jung B, Saif T. Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review. Comput Struct Biotechnol J. 2018 Jul 27;16:279-287. doi: 10.1016/j.csbj.2018.07.003. PMID: 30128085; PMCID: PMC6097544.
Spill F, Reynolds DS, Kamm RD, Zaman MH. Impact of the physical microenvironment on tumor progression and metastasis. Curr Opin Biotechnol. 2016 Aug;40:41-48. doi: 10.1016/j.copbio.2016.02.007. Epub 2016 Mar 2. PMID: 26938687; PMCID: PMC4975620.

Planned Learning Activities and Teaching Methods

Lectures, the topics with classroom activities (presentations and homework assignments) to consolidate and discussion

Assessment Methods

Further Notes About Assessment Methods

None

Assessment Criteria

1. The student will clearly define outlined LO1, LO2, LO3, LO4 which will evaluate with exam.
2. The student will recognize LO5, LO6 with homework, prepared presentations by themselves and exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gizem.calibasi@deu.edu.tr

Office Hours

By appointment, Thursday 13:00-14:00

Work Placement(s)

None

Workload Calculation

Contribution of Learning Outcomes to Programme Outcomes