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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS MDF 6014 RADIOBIOLOGY ELECTIVE 2 0 0 6

Offered By

Medical Physics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR AYŞE NUR DEMIRAL

Offered to

Medical Physics

Course Objective

To gain adequate knowledge of tumor and normal tissue radiobiology and its clinical implications in order to understand the basis of diagnostic and treatment strategies in Radiology, Nuclear Medicine, and Radiation Oncology

Learning Outcomes of the Course Unit

1   Ability to comprehend the basis of tumor and normal tissue radiobiology 2   Demonstrate a basic understanding of the interaction of different drugs used in cancer treatment with radiotherapy and ability to understand how this interaction affects tumor and normal tissue radiosensitivity; 3   Demonstrate a basic understanding of the radiobiological basis of different treatment strategies used in radiotherapy; 4   Ability to implement radiobiological knowledge to the diagnostic and therapeutic applications of ionizing radiation

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Introduction: Radiobiology 2 Cell survival curves 3 The effects of radiation on tumor cells 4 The effects of radiation on normal tissues 5 Time-dose-fractionation in radiotherapy and different fractionation schemes 6 LET, RBE, quality factor, BED Formula and calculations 7 The radiobiological effect of dose-rate in brachytherapy 8 Particular radiation used in radiotherapy and its radiobiological effects 9 Interaction of radiotherapy and chemotherapy 10 Radiosensitizers 11 Radioprotectors 12 The acute effects of total body irradiation 13 Radiation cancerogenesis 14 Hereditary effects of radiation The effects of radiation on embryo and fetus

Recomended or Required Reading

Radiobiology for the Radiologist, Eric J Hall, sixth edition, Lippincott Williams&Wilkins, 2006 Basic Clinical Radiobiology, M Joiner, A. Van der Kogel, fourth edition, Hodder Arnold, 2009 Basic Clinical Radiobiology, G Steel, Arnold, 2009 Course Materials: slides

Planned Learning Activities and Teaching Methods

Lecturing Active participation to the lecture Homework

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 MTE MIDTERM EXAM 2 ASG ASSIGNMENT 3 FIN FINAL EXAM 4 FCGR FINAL COURSE GRADE MTE * 0.30 + ASG * 0.20 + FIN* 0.50 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.30 + ASG * 0.20 + RST* 0.50 *** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Prof. Ayşe Nur Demiral, M.D. Dokuz Eylül University Medical School Dept .of Radiation Oncology Tel: 4124210 aysenurdeu@gmail.com

Office Hours

Friday 13.30-14.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 2 28 Preparations before/after weekly lectures 14 3 42 Preparation for midterm exam 1 20 20 Preparation for final exam 1 36 36 Preparing assignments 1 20 20 Final 1 2 2 Midterm 1 2 2 TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 PO.9 PO.10 PO.11 PO.12 PO.13 PO.14 PO.15 PO.16 PO.17 PO.18 LO.1 5 3 5 5 3 LO.2 4 4 3 LO.3 5 3 5 4 3 LO.4 3 5 4 3