COURSE UNIT TITLE

: MOLECULAR MEDICINE: MOLECULAR MECHANISMS IN DIAGNOSIS AND TREATMENT APPROACHES OF DISEASES

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MOT 6044 MOLECULAR MEDICINE: MOLECULAR MECHANISMS IN DIAGNOSIS AND TREATMENT APPROACHES OF DISEASES ELECTIVE 3 0 0 9

Offered By

Molecular Medicine

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSISTANT PROFESSOR MEHTAP YÜKSEL EĞRILMEZ

Offered to

Molecular Medicine
Molecular Medicine

Course Objective

Recent studies highlightened the molecular mechanisms of the diseases in detail. This resulted in developing new approaches to the diagnosis and treatment of the diseases. The aim of this course is to study the diseases systemically and to discuss the molecular mechanisms of diseases such as cancer, diabetes, atherosclerosis, and to analyse the molecular targets for the diagnosis and to evaluate new therapy trends.

Learning Outcomes of the Course Unit

1   Define and recall the mechanisms of the diseases and molecular approaches for the diagnosis and treatment of the diseases
2   Describe the theoretical basis of the mechanisms of the diseases and molecular approaches for the diagnosis and treatment of the diseases
3   Analyse the relationship between mechanisms of the diseases and molecular approaches for the diagnosis and treatment of the diseases
4   Discuss the mechanisms of the diseases and molecular approaches for the diagnosis and treatment of the diseases (Ex: Gene therapy)
5   Evaluate the materials design which makes diagnosis and treatment more effective and compare the advantages of these materials with traditional systems
6   Design new molecular approaches for the diagnosis and treatment of the diseases by using the mechanisms of the diseases

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction Overview of Molecular Mechanisms of Diseases Molecular Approaches to Diagnosis and Treatment of Diseases
2 Molecular Mechanisms of Carsinogenesis Nuclear Copying and Cell Cycle Regulatory Molecules Cell Growth and Molecular Mechanisms of DNA Repair Oncogenes, Tumour Supressor Genes, Apoptotic Genes
3 Cell Adhesion Regulatory Molecules Molecules Regulating Cell Signaling Acquired Environmental Carcinogens Biology of Tumour Growth; Molecular Mechanisms of Angiogenesis, Invasion and Angiogenesis
4 Molecular Mechanisms of Metabolic Disorders Molecular Approaches to Diagnosis and Treatment of Metabolic Disorders
5 Molecular Mechanisms of Gastrointestinal Diseases Molecular Approaches to Diagnosis and Treatment of Gastrointestinal Diseases
6 Primary and secondary adipocyte dysfunction in insulin resistance
7 Molecular Mechanisms of Lipodystrophies Molecular Approaches to Diagnosis and Treatment of Lipodystrophies
8 Molecular Mechanisms of Systemic Sclerosis Molecular Approaches to Diagnosis and Treatment of Systemic Sclerosis
9 Molecular Mechanisms of Systemic Lupus Erythematosus Molecular Approaches to Diagnosis and Treatment of Systemic Lupus Erythematosus
10 Molecular Mechanisms of Rheumatoid Arthritis Molecular Approaches to Diagnosis and Treatment of Rheumatoid Arthritis
11 Molecular Mechanisms of Atherosclerosis Molecular Approaches to Diagnosis and Treatment of Atherosclerosis
12 Molecular Mechanisms of Wound Healing Molecular Approaches to Diagnosis and Treatment of Wound Healing
13 Molecular Mechanisms of Obstructive Sleep Apnea Syndrome Molecular Approaches to Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome
14 Gene Therapy
15 Student presentations
16 Final Exam

Recomended or Required Reading

1. Molecular Medicine: An introduction. Jens Kurreck, Cy Aaron Stein. John Wiley & Sons, 2015.
2. Textbook of Clinical Chemistry and Molecular Diagnostics. Eds: Burtis CA, Ashwood ER, Bruns DE, 4th edition, 2006, Elsevier Saunders, St Louis.
3. Biology of Disease. Eds: Ahmed N, Dawson M, Smith, Wood E, 2007, Taylor & Francis Group, New York.
4. Harper's Illustrated Biochemistry Murray, Bender, Rotham, Kennelly Rodwell and Weil, 28th Edition, 2009,McGraw Hill International Edition.
5. Textbook of Biochemistry with Clinical Correlations. Thomas M. Devlin. Seventh Edition 2011, John-Wiley& Sons Inc. Publication, USA.
6. Functional Biochemistry in Health and Disease. Newsholme, EA and Leech, TR. 2010, WILEY-BLACKWELL, Oxford.
7. Inborn Metabolic Disease. Fernandes J, Saudubray JM, Berghe G, Walter JH. Fourth edition 2006, Springer Medizin Verlag Heidelberg, Germany.
8. Temel Pediatri. Hasanoğlu E, Düşünsel R, Bideci A. Birinci baskı, 2010, Güneş Tıp Kitabevi, Ankara.

Planned Learning Activities and Teaching Methods

The course will be run in an integrated way-winding theory with case discussion. The methods of learning will be interactive.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 PAR PARTICIPATION
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE ASG * 0.30 +PAR * 0.30 +FIN* 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 +PAR * 0.30 +RST* 0.40


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

The student is expected to read the resources before coming to class. In addition, he/she is expected to contribute actively to discussion, group-work and case study practices. Plagiarism of any type will result in disciplinary action.

Contact Details for the Lecturer(s)

Assist. Prof. Dr. Mehtap Yüksel Eğrilmez

Email: mehtap.yuksel@deu.edu.tr Phone: 412 2606

Office Hours

Mondays 12.30-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 45 3 135
Preparations before/after weekly lectures 45 1 45
Preparation for final exam 1 20 20
Preparing assignments 1 11 11
Preparing presentations 1 11 11
Final 1 3 3
TOTAL WORKLOAD (hours) 225

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14
LO.155111115555115
LO.255111115555115
LO.355115515555115
LO.455115555555115
LO.555555555555555
LO.655555555555555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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