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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BIO 6010 BIOCHEMISTRY OF EXTRACELLULAR MATRIX ELECTIVE 2 0 4

Offered By

Bioengineering (English)

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

Offered to

Bioengineering (English)

Course Objective

The aim of this course is to understand the structure, physiological roles and regulation of extracellular matrix and to synthesize the knowledge on extracellular matrix components and interactions related to human disease using clinical cases. In addition, the principles of methods detecting extracellular matrix components will be studied.

Learning Outcomes of the Course Unit

1   Define the term extracellular matrix and roles of extracellular matrix 2   Learn the structure and physiological roles of extracellular matrix components 3   Classify the enzymes regulating the ECM and understand the regulation mechanisms at tanscriptional and translational level of theses enzymes 4   Explain several molecular mechanism underlying various disesaes based on abnormal extacellular matrix regulation 5   Discuss the principle of techniques using analysis of extracellular matrix components.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Introduction to Extracellular matrix 2 Structure and Functions of Collagen and Elastin 3 Adhesive Glycoproteins 4 Matrix Proteoglycans 5 Case Studies 6 Extracellular Matrix Remodelling and Turnover 7 Matrix Metalloproteinases: Inhibitors, activators and signalling 8 Wound Healing and Extracellular Matrix 9 Tumour invasion/metastasis and metastasis 10 Fibrosis and Extracellular matrix 11 Intervebtebral disc and Extracellular matrix 12 Bone and Extracellular matrix 13 Techniques using for detection of extracellular matrix components 14 Presentation and discussion of articles related to topics 15 Presentation and discussion of articles related to topics

Recomended or Required Reading

1. Newsholme, EA and Leech, TR. Functional Biochemistry in Health and Disease 2010, WILEY-BLACKWELL, Oxford. 2. Extracellular matrix, Volume 1, Tissue Function, Wayne D.Comper, Harwood Academic Publisher, 1996. 3. Extracellular matrix, Volume 2, Molecular Components and Interactions, Harwood Academic Publisher, 1996. 4. Current reviews

Planned Learning Activities and Teaching Methods

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 FIN FINAL EXAM 3 FCG FINAL COURSE GRADE ASG * 0.50+ FIN* 0.50 4 RST RESIT 5 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.50+ RST* 0.50 *** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

hasan.havitcioglu@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 15 4 60 Preparations before/after weekly lectures 20 1 20 Final 1 20 20 TOTAL WORKLOAD (hours) 100

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 LO.1 4 LO.2 3 LO.3 3 LO.4 3 LO.5 3