COURSE UNIT TITLE

: EXTRACELLULAR MATRIX AND DYNAMICS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ERS 6009 EXTRACELLULAR MATRIX AND DYNAMICS ELECTIVE 1 0 0 10

Offered By

Biochemistry

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR GÜLGÜN OKTAY

Offered to

Biochemistry

Course Objective

The aim of this course is to understand the structure, physiological roles and regulation of extracellular matrix and to synthesize the knowledge on extracellular matrix components and interactions related to human disease using clinical cases. In addition, the principles of methods detecting extracellular matrix components will be studied.

Learning Outcomes of the Course Unit

1   Define the term extracellular matrix and roles of extracellular matrix
2   Learn the structure and physiological roles of extracellular matrix components
3   Classify the enzymes regulating the ECM and understand the regulation mechanisms at tanscriptional and translational level of theses enzymes
4   Explain several molecular mechanism underlying various disesaes based on abnormal extacellular matrix regulation
5   Discuss the principle of techniques using analysis of extracellular matrix components.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to Extracellular matrix
2 Structure and Functions of Collagen and Elastin
3 Adhesive Glycoproteins
4 Matrix Proteoglycans
5 Case Studies
6 Extracellular Matrix Remodelling and Turnover
7 Matrix Metalloproteinases: Inhibitors, activators and signalling
8 Wound Healing and Extracellular Matrix
9 Tumour invasion/metastasis and metastasis
10 Fibrosis and Extracellular matrix
11 Intervebtebral disc and Extracellular matrix
12 Bone and Extracellular matrix
13 Techniques using for detection of extracellular matrix components
14 Presentation and discussion of articles related to topics

Recomended or Required Reading

1. Newsholme, EA and Leech, TR. Functional Biochemistry in Health and Disease 2010, WILEY-BLACKWELL, Oxford.
2. Extracellular matrix, Volume 1, Tissue Function, Wayne D.Comper, Harwood Academic Publisher, 1996.
3. Extracellular matrix, Volume 2, Molecular Components and Interactions, Harwood Academic Publisher, 1996.
4. Current reviews

Planned Learning Activities and Teaching Methods

The course will be run in an integrated way-winding theory with case discussion and laboratory practicals. The methods of learning will be interactive.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 FIN FINAL EXAM
4 FCGR FINAL COURSE GRADE MTE * 0.30 + ASG * 0.20 + FIN* 0.50
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.30 + ASG * 0.20 + RST* 0.50


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

Textbook(s)/References/Materials:
1. Newsholme, EA and Leech, TR. Functional Biochemistry in Health and Disease 2010, WILEY-BLACKWELL, Oxford.
2. Extracellular matrix, Volume 1, Tissue Function, Wayne D.Comper, Harwood Academic Publisher, 1996.
3. Extracellular matrix, Volume 2, Molecular Components and Interactions, Harwood Academic Publisher, 1996.
4. Current reviews

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

The student is expected to read the resources before coming to class.

Contact Details for the Lecturer(s)

Prof.Dr.Gülgün Oktay
Phone: 412 4402
gulgun.oktay@deu.edu.tr

Office Hours

Mondays 12.30-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 6 90
Preparations before/after weekly lectures 15 6 90
Preparing assignments 6 10 60
TOTAL WORKLOAD (hours) 240

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13
LO.1554
LO.2554
LO.3554
LO.4554
LO.55544344

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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