COURSE UNIT TITLE

: EXPERIMENTAL METHODS IN PHARMACOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
FAR 5008 EXPERIMENTAL METHODS IN PHARMACOLOGY COMPULSORY 2 8 0 12

Offered By

Pharmacology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR MUKADDES GÜMÜŞTEKIN

Offered to

Pharmacology
Toxicology

Course Objective

Animal experimental methods and the care of experimental animals are essential parts of the course, including theoretical aspects as well as practical training. Experimental pharmacological methods are introduced, including operation techniques and in vitro experiments with excised tissues or organs. Within this course, a number of subjects are treated in some length. These subjects include organ bath studies, the Langendorff technique of isolated heart perfusion, pharmacokinetic studies, in vivo rat models of the measurement of blood pressure and ECG monitoring and etc.

Learning Outcomes of the Course Unit

1   be able to define the concepts and general information about the experimental methods in pharmacology
2   be able to compare in vivo and in vitro experimental methods
3   be able to understand the principles of experimental methods
4   be able to evaluate and identify the results of experimental studies
5   be able to know, predict and solve the problems which related of experimental studies

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 General principles for the care and use of animals for scientific purposes and animal housing and management
2 The routes of administration of drugs in experimental animals and dose calculation of drugs General principles and techniques of anesthesia and sedation in laboratory animals.
3 The principles of preoperative management in in vitro and in vivo experiments
4 Tissue Organ Bath Principles and techniques
5 The principles of administration agonist or antagonist to organ bath, dose response studies and concentration-response relationships in isolated tissue preparations.
6 Assessment of agonist /antagonists effects in organ bath, Dose-response assessment, the concept of PD2 and PA2 and the calculation of EC50 and IC50
7 Mid-term exam
8 The principles of isolated heart preparation and experimental set-up
9 Asssesment of cardiac functions in isolated heart tissue by Langerdorf methods
10 Methods and techniques of carotid artery and jugular vein cannulation and endotracheal intubation
11 In vivo rat models of the measurement of blood pressure and ECG monitoring
12 Techiques of isolated aorta preparation
13 Techiques of isolated corpus cavernosum preparation
14 Techiques of isolated detrusor muscle preparation The principles of cell culture and using in pharmacology and toxicology
15 Final exam

Recomended or Required Reading

Textbook(s):
1- The Laboratory Rat, A Volume in The Laboratory Animal Pocket Reference Series. Ed. Mark A.Suckow, D.V.M., CRC Press (1998).
2- Manual of Microsurgery on the Laboratory Rats (1990).

Supplementary Book(s):
1- Manual for Laboratory Work in Mammalian Physiology (Fred D Amour).
2- Manual of Pharmacologic Calculations with Computer Programs (1987).
3- Experimental and Surgical Technique in the Rat-2. Ed (1992).
4- Deneysel Mikrocerrahi Temel Araştırma, Doku ve Organ Nakli Modelleri, Mehmet Bayramiçli.
5- Deney Hayvanları Kurs notları, Ege Üniversitesi (1999).
6- Deney Hayvanları, Prof. Dr. Nuri Yavru, Konya (1996).

Planned Learning Activities and Teaching Methods

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRF PERFORMANCE
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 + FIN* 0.60
5 RST RESIT
6 FCGR FINAL COURSE GRADE MTE * 0.20 +PRF * 0.20 +RST* 0.60


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

Students are expected to make power point presentation related a subject from experimental methods in pharmacology and toxicology

Assessment Criteria

Students achievement will be measured by passing the mid-term exam and final exam and also making power point presentation related to a subject from course program.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gumustek@deu.edu.tr, telephone number: 4123906

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 2 26
Practices 13 8 104
Preparation for Mid-term Exam 1 14 14
Preparation forFinal Exam 1 34 34
Preparing Presentations 1 14 14
Preparation before/after weekly lectures 13 8 104
Mid-term 1 2 2
Final 1 2 2
TOTAL WORKLOAD (hours) 300

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8
LO.155233353
LO.245453553
LO.355353353
LO.455533453
LO.545553553

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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