COURSE UNIT TITLE

: MOLECULAR BASIS OF CANCER

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TBG 5032 MOLECULAR BASIS OF CANCER ELECTIVE 2 0 0 4

Offered By

Medical Biology and Genetics

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR HAKKI OGÜN SERCAN

Offered to

Medical Biology and Genetics
Molecular Medicine
CLINICAL DRUG RESEARCH
Pharmacology

Course Objective

Objectives of this course are:
*To learn the molecular basics of cancer
*To acquire basic knowledge on the concepts and processes that causes malign transformation of the cell
*To gain an understanding of carsinogenesis

Learning Outcomes of the Course Unit

1   Knows and uses the correct nomenculature in topics related to malign transformation and cancer
2   Lists the biological differences between normal and transformed cells.
3   Recounts different carcinogenesis theories; defines the concept of clonality.
4   Knows and repeats the activation/deactivation mechanisms and features of oncogenes and tumour suppressor genes
5   Describes cellular functions that have changed in malign transformation (proliferation, cell death, signal transduction, cell-cell interactions and adhesion molecules)
6   Describes the cell skeleton and its role in cell motility & mobility
7   Explains the concept and characteristics of a stem cell ; lists differentiation control mechanisms

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction
2 Definition of Cancer & the Nomenculature
3 General Biological Features of the Cancer Cell
4 Carcinogenesis Theories & Clonality
5 Predisposition to Cancer: Oncogenes & TSGs I
6 Predisposition to Cancer: Oncogenes & TSGs II
7 Biochemistry of the Cancer Cell
8 DNA Repair & Cancer
9 MID-TERM EXAM
10 Changed Cellular Functions in the Transformed Cell: Proliferation
11 Changed Cellular Functions in the Transformed Cell: Cell Death
12 Changed Cellular Functions in the Transformed Cell: Signal Transduction
13 Changed Cellular Functions in the Transformed Cell: Cell-Cell Interaction, Adhesion Molecules & Metastasis
14 Changed Cellular Functions in the Transformed Cell: The Stem Cell & Diferantiation
15 FINAL EXAM

Recomended or Required Reading

Textbook(s):
1. Hücre, Moleküler Yaklaşım, (The Cell, A Molecular Approach 2nd edition Geoffey M. Cooper, Robert E. Hausman.) Çeviri Editörleri: Meral Sakızlı, Neşe Atabey. Izmir Tıp Kitabevi, ISBN: 9944-5148-0-2, Ankara 2006 .
2. Hücrenin Moleküler Biyolojisi, (Molecular Biology of the Cell,4th Edition. Ed. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishers) Çeviri Editörleri: Nur Buyru, Nejat Dalay, Meral Özgüç, Mehmet Öztürk, Meral Sakızlı, ISBN: 978-9944-252-22-5, TÜBA ders kitapları, 2008
Supplementary Book(s):
References:
Materials:

Planned Learning Activities and Teaching Methods

Lectures: Basic theoretical concepts will be explained during lectures
Homework: Students are expected to hand in 4 written reports on topics that are given by the course coordinator.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE MTE * 0.40 + FIN* 0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE MTE * 0.40 + RST* 0.60


*** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Tel: 412 4623 E-posta: zeynep.sercan@deu.edu.tr

Office Hours

Wednesdays 15:30-17:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 2 28
Preparation before/after weekly lectures 14 3 42
Preparation for midterm exam 1 6 6
Preparation for final exam 1 10 10
Preparing Individual Assignments 3 6 18
Final 1 3 3
Midterm 1 3 3
TOTAL WORKLOAD (hours) 110

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8
LO.111311111
LO.211311111
LO.311311111
LO.411311111
LO.511311111
LO.611311111
LO.711311111

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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