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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BYL 5077 MOLECULAR BIOLOGY OF CANCER ELECTIVE 3 0 0 6

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSISTANT PROFESSOR ASLI SADE MEMIŞOĞLU

Offered to

Ph.D. in Biology Biology

Course Objective

To understand the basic molecular changes and disrupted signalling pathways that lead to cancer and follow recent developments in the area

Learning Outcomes of the Course Unit

1   To understand cancer biology 2   To understand the molecular events leading to cancer 3   To comprehend the multifaceted nature of cancer 4   Have information on the current treatment regimen for cancer 5   To follow and interpret recent cancer research

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Introduction,Cancer Defined, History of Cancer Research Overview of the hallmarks of cancer 2 Mutagens, carcinogens, and mutations Tumor viruses and the discovery of oncogenes Tumor cells possess genetic abnormalities 3 Mechanisms of oncogene activation Role of growth factors and receptors in carcinogenesis 4 RAS signaling in cancer Familial cancer syndromes and the discovery of tumor suppressors 5 Cell cycle control and the pRb tumor suppressor Apoptosis and the p53 tumor suppressor 6 Cellular senescence Telomeres, cellular immortalization, and tumorigenesis 7 Multi-step tumorigenesis and the evolution of cancer Tumor-promoting stimuli and cancer stem cells 8 Midterm 9 DNA repair mechanisms DNA repair defects and their relationship to cancer 10 Angiogenesis and Metastasis 11 Tumor Immunology and Cancer cell metabolism 12 Treatment- traditional chemotherapeutics Treatment- Immunotherapies 13 Treatment-targeted therapy. New Genomic and proteomic technologies Applications of new technologies in prevention, diagnostics and treatment 14 Final exam

Recomended or Required Reading

Baran, Y. (2018). Kanser Moleküler Biyolojisi. Kısayol Yayıncılık. Ankara Weinberg, R. A. (2014). The Biology of Cancer. 2nd edition. Garland Science, Taylor and Francis Group, New York. Articles to be assigned during the course

Planned Learning Activities and Teaching Methods

The course will consist of lectures, paper discussions, presentations, question and answers

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40 *** Resit Exam is Not Administered in Institutions Where Resit is not Applicable.

Further Notes About Assessment Methods

None

Assessment Criteria

Research paper discussions during the semestre, mid-term and final exam

Language of Instruction

Turkish

Course Policies and Rules

The students have to continue to the class as 70% in a term

Contact Details for the Lecturer(s)

asli.memisoglu@deu.edu.tr

Office Hours

To be announced later

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 12 3 36 Preparations before/after weekly lectures 10 8 80 Preparation for midterm exam 1 15 15 Preparation for final exam 1 15 15 Final 1 2 2 Midterm 1 2 2 TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 PO.9 PO.10 PO.11 PO.12 LO.1 5 1 5 1 4 2 2 2 2 5 4 3 LO.2 3 1 5 2 4 2 2 3 4 5 5 5 LO.3 3 1 5 1 5 2 3 4 4 5 5 2 LO.4 5 5 5 2 5 5 5 5 5 5 2 1 LO.5 5 5 5 1 5 5 5 5 5 5 2 1