COURSE UNIT TITLE

: INTRODUCTION TO ORGANOIDS FROM DIAGNOSIS TO TREATMENT

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ELECTIVE

Offered By

Translational Oncology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSOCIATE PROFESSOR GIZEM ÇALIBAŞI KOÇAL

Offered to

Translational Oncology

Course Objective

Advances in in vitro 3D culture technologies with organoids have opened new avenues for the development of cancer models for further research. Such preclinical models are essential for more efficient translation of basic cancer research into new treatment regimens for patients with cancer. Normal tissue organoids can be grown from embryonic and adult stem cells and exhibit self-organizing capacities, embodying essential features of the organs from which they are derived. Genetic modification of organoids by gene editing technologies allows disease modeling in an environment approaching the physiological environment. In addition to all these, organoids can be grown with high efficiency from patient-derived tumor tissues. Thus, advances with organoid technology potentially allow for the development of patient-specific drug testing and individualized treatment regimens.

Learning Outcomes of the Course Unit

1   Gaining knowledge about the concept of lab-on-a-chip.
2   Gaining knowledge about micro-scale in vitro disease and cancer models.
3   Learning about Organoids-on-a-chip.
4   Having information about Lab-on-a-chip devices and laboratory analysis.
5   Learning about lab-on-a-chip devices and translation to the clinic.
6   Understanding researches done with lab-on-a-chip devices.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 An Introduction to Lab-on-a-chip devices
2 Design and fabrication processes
3 Microscale in vitro disease models
4 Microscale in vitro cancer models for tumor biology
5 Organoids-on-a-chip
6 Lab-on-a-chip devices for molecular diagnosis
7 Lab-on-a-chip devices for Point-of-Care (POC) medical diagnostics
8 Lab-on-a-chip for drug discovery
9 Lab-on-a-chip in cancer imaging
10 Challenges in product development an commercialization
11 Translation to clinic-1: Application and products
12 Translation to clinic-2: Application and products
13 Translation to clinic-3: Application and products
14 Discussion with literature
15 Discussion with literature

Recomended or Required Reading

Arshavsky-Graham S., Segal E. (2020) Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics. In: . Advances in Biochemical Engineering/Biotechnology. Springer, Berlin, Heidelberg.
Lab-on-a-Chip Miniaturized Systems for (Bio)Chemical Analysis and Synthesis. Editors: Edwin Oosterbroek, A. van den Berg. 1st Edition - October 2, 2003. eBook ISBN: 9780080509884
Yu F, Hunziker W, Choudhury D. Engineering Microfluidic Organoid-on-a-Chip Platforms. Micromachines (Basel). 2019 Feb 27;10(3):165.
Park SE, Georgescu A, Huh D. Organoids-on-a-chip. Science. 2019;364(6444):960-965.
Sachdeva S, Davis RW, Saha AK. Microfluidic Point-of-Care Testing: Commercial Landscape and Future Directions. Front Bioeng Biotechnol. 2021 Jan 15;8:602659.

Planned Learning Activities and Teaching Methods

Theoretical lectures, reinforcement and discussion of the subjects with in-class activities (presentations and assignments)

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE ASG * 0.50+ FIN* 0.50
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.50+ RST* 0.50


Further Notes About Assessment Methods

None

Assessment Criteria

With homework and presentation (LO 2,3, and 6)
With exam (LO 1,2,3,4,5,6)

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gizem.calibasi@deu.edu.tr ; 0 232 412 58 35

Office Hours

Tuesday 14:00-15:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
TOTAL WORKLOAD (hours) 0

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.155555
LO.255555
LO.355555
LO.455555
LO.555555
LO.65555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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