COURSE UNIT TITLE

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology

Course Objective

In the light of new developments in the field of oncology, it is possible to gain basic information about liquid biopsies and their areas of use and to continue the projects and scientific studies on the subject.

Learning Outcomes of the Course Unit

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Recomended or Required Reading

Cancer: Principles and Practice of oncology, 12th Edition, DE vita
Altun ZS. Rna dan Ve Proteoformlara Temel Araştirma Yöntemleri. Klinisyenler Için Temel Onkoloji. 1. Baskı
Ankara: Türkiye Klinikleri; 2021. p.102- 5. 2021 e-Isbn: 978-625-401-395-9. Alix-Panabieres, C., and Pantel, K. (2014). Technologies for detection of circulating tumor cells: facts and vision. Lab on a chip 14, 57-62.
Ashworth, T.R. (1869). A case of cancer in which cells similar to those in the tumours were seen in the blood after death. Australian Medical Journal, 146-147.
Banys, M., Neubauer, H., Ruckhaeberle, E., and Fehm, T. (2014). Expression of Stem Cell and Epithelial-Mesenchymal Transition Markers in Circulating Tumor Cells of Breast Cancer Patients. BioMed research international.
Butler, T.P., and Gullino, P.M. (1975). Quantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer research 35, 512-516.
Coumans, F.A., Siesling, S., and Terstappen, L.W. (2013). Detection of cancer before distant metastasis. BMC cancer 13, 283.
Fidler, I.J. (1970). Metastasis: guantitative analysis of distribution and fate of tumor embolilabeled with 125 I-5-iodo-2'-deoxyuridine. Journal of the National Cancer Institute 45, 773-782.
Fidler, I.J. (1973). The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis. European journal of cancer 9, 223-227.
Friberg, S., and Mattson, S. (1997). On the growth rates of human malignant tumors: implications for medical decision making. J Surg Oncol 65, 284-297.
Husemann, Y., Geigl, J.B., Schubert, F., Musiani, P., Meyer, M., Burghart, E., Forni, G., Eils, R., Fehm, T., Riethmuller, G., et al. (2008). Systemic spread is an early step in breast cancer. Cancer cell 13, 58-68.
Jin, C., McFaul, S.M., Duffy, S.P., Deng, X., Tavassoli, P., Black, P.C., and Ma, H. (2014). Technologies for label-free separation of circulating tumor cells: from historical foundations to recent developments. Lab on a chip 14, 32-44.

Tai YL, Chen KC, Hsieh JT, Shen TL. Exosomes in cancer development and clinical applications. Cancer Sci. 2018 Aug;109(8):2364-2374. doi: 10.1111/cas.13697. Wong, I.Y., Javaid, S., Wong, E.A., Perk, S., Haber, D.A., Toner, M., and Irimia, D. (2014). Collective and individual migration following the epithelial-mesenchymal transition. Nature materials.
Yu, M., Bardia, A., Aceto, N., Bersani, F., Madden, M.W., Donaldson, M.C., Desai, R., Zhu, H., Comaills, V., Zheng, Z., et al. (2014). Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science 345, 216-220.Zhu L, Sun HT, Wang S, Huang SL, Zheng Y, Wang CQ, Hu BY, Qin W, Zou TT, Fu Y, Shen XT, Zhu WW, Geng Y, Lu L, Jia HL, Qin LX, Dong QZ. Isolation and characterization of exosomes for cancer research. J Hematol Oncol. 2020 Nov 10;13(1):152. doi: 10.1186/s13045-020-00987-

Planned Learning Activities and Teaching Methods

Theoretical lectures, reinforcement and discussion of the subjects with in-class activities, scientific literature, presentations and assignments. Students are also required to prepare and present a research proposal on liquid biopsies and cancer.

Assessment Methods

Further Notes About Assessment Methods

Students should actively participate in lectures and literature etc discussions about liquid biopsy. He/she should prepare a review or research article that includes current changes with the subject. Each student should create and present self-written and actually applicable research that covers current issues related to liquid biopsies and cancer.

Assessment Criteria

Students should actively participate in lectures and literature vs. discussions about liquid biopsy. Students should evaluate their knowledge about the subject as an exam about liquid biopsies and their usage area. He/she should prepare a homework presentation that includes current changes with the subject.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

zekiye.altun@deu.edu.tr, Tel: +90(232)4128204

Office Hours

on Tuesday at: Tuesday hours: 13.00-13.30

Work Placement(s)

None

Workload Calculation

Contribution of Learning Outcomes to Programme Outcomes