COURSE UNIT TITLE

: ENZYMOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BIO 6063 ENZYMOLOGY ELECTIVE 2 0 0 6

Offered By

Biochemistry

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR SEZER UYSAL

Offered to

Biochemistry

Course Objective

Within the frame of this course, the following topics and concepts are inteded to be discussed at an advanced level:
Historical aspects of enzymology, nomenclature and classification of enzymes, concept of substrate specificity and mecanisms, coenzymes, types, accociated reactions and role in metabolism, control of enzymatic reactions, , enzimatik aktivitenin kontrolü, velocity of enzymatic reactions, chemical kinetics, enzymatic kinetics, inhibition and types, effect of pH, bi-substrate reactions, derivation of Michaelis-menten equation; mecanisms of enzyme catalysis, enzymatic reaction mecanim using the lysosyme example; serine proteases; drug desing, introduction to pharmacology, introduction to clinical enzymology

Learning Outcomes of the Course Unit

1   Learn enyzme definition, classification, general properties of enzymes, enzyme catalysis and catalysis mechanisms at an advanced level
2   Be able to transfer knowledge about basic enzymology to different conditions
3   Understand the different catalysis types and discuss them using different examples
4   Gain skills for transfering basic enzymology information on drug design
5   Starting with enzyme inhibition types, be able to analyse events taking place in the organism and compare the basics of different applications of enzyme therapy
6   Understand the use of different enzymes in clinical enzymology
7   Using the information learned as well as searching new information, prepare and make an oral presentation on a topic in enzymology

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to Enzymology- basic concepts, Enzyme nomenclature and classification of enzymes, Chemical kinetics, Enzyme kinetics, Enzyme inhibition and types, Problem solving- enzyme kinetics, Use of enzymes in Clinical Laboratory- General principles, Enzyme localisation- Use of enzymes in therapy and in reagents
2 Three-dimensional imaging of biomolecules and enzymes-Introduction, Imaging of three-dimensional structure of enzymes using J-Mole (I), Imaging of three-dimensional structure of enzymes using J-Mole (II), Imaging of three-dimensional structure of enzymes using J-Mole (III), STUDENT PRESENTATIONS-General Discussion (Whole Group)

Recomended or Required Reading

Textbook(s)/References/Materials:
1. Harper s Illustrated Biochemistry 28th Edition, 2009 , Murray, Bender, Rotham, Kennelly
Rodwell and Weil.McGraw Hill International Edition.pp51-83.
Yardımcı kaynaklar:
2. Textbook of Biochemistry with Clinical Correlations. Seventh Edition 2011, Thomas M. Devlin. John-Wiley& Sons Inc. Publication, USA , pp. 377-418.
3. Textbook of Clinical Chemistry and Molecular Diagnostics. Eds: Burtis CA, Ashwood ER, Bruns DE, 4th edition, 2006, Elsevier Saunders, St Louis.
4. Newsholme, EA and Leech, TR. Functional Biochemistry in Health and Disease 2010, WILEY-BLACKWELL, Oxford, pp 35-68.
5. Bisswanger, H. Practical Enzymology 2011, WILEY-BLACKWELL.

Planned Learning Activities and Teaching Methods

Lectures, small group sessions, problem solving, making a presentation

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCGR FINAL COURSE GRADE MTE * 0.30 + ASG * 0.20 +PAR* 0.10 + FIN*0.40
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.30 + ASG * 0.20 +PAR* 0.10 + RST*0.40


Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Emel ALTEKIN
Phone: 412 44 12

Office Hours

Mondays 12.30-13:00, Department of Medical Biochemistry

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 10 2 20
Tutorials 10 1 10
Preparations before/after weekly lectures 10 4 40
Preparation for midterm exam 1 20 20
Preparation for final exam 1 40 40
Preparing presentations 1 15 15
Final 1 3 3
Midterm 1 2 2
TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13
LO.154
LO.2544
LO.3544
LO.4544
LO.55
LO.6555
LO.74555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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