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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BST 6019 CHROMATIN AND TRANSCRIPTION ELECTIVE 3 0 0 12

Offered By

Biomedicine and Health Technologies

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR HANI ALOTAIBI

Offered to

Biomedicine and Health Technologies

Course Objective

This course covers a broad overview of mechanisms for transcriptional regulation. It covers basic mechanisms of transcriptional regulation in prokaryotes, eukaryotes, and transcriptional regulation through chromatin.

Learning Outcomes of the Course Unit

1   Understand the basic transcriptional machinery 2   Understand the basic rules of transcriptional regulation, including how transcriptional activators function. 3   Understand how cis-elements, such as promoters and enhancers, function. 4   Understand how chromatin structure is regulated for transcriptional control. 5   Learn examples of transcriptional regulation during development and disease

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 The basal transcriptional machinery 2 Pol II function, pausing and the role of RNA in transcription 3 Promoter-specific and regional regulation of transcription 4 Activators and enhancer function 5 Long range transcriptional regulation and enhancers 6 Boundaries CTCF 7 Histone Dynamics Nucleosome Displacement 8 Midterm 9 Histone Variants 10 Chromatin modifications and transcription 11 ATP-dependent chromatin remodelling 12 Histone Modifying enzymes 13 Chromatin landscape in cancer 14 Dynamic and complex patterns of gene expression 15 High throughput analysis Next generation sequencing - Histones 16 Final Exam

Recomended or Required Reading

Recent Literature

Planned Learning Activities and Teaching Methods

Discussion based, Problem oriented.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

hani.alotaibi@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Preparations before/after weekly lectures 14 8 112 Preparation for final exam 1 30 30 Preparing assignments 2 20 40 Preparing assignments 1 20 20 Preparing presentations 2 15 30 Project Preparation 1 25 25 Final 1 5 5 TOTAL WORKLOAD (hours) 304

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 5 5 LO.2 5 5 LO.3 5 5 5 LO.4 5 5 5 5 LO.5 5 5 5