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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS MBG 5040 INTRODUCTION TO BIOPROCESS ENGINEERING ELECTIVE 3 0 0 9

Offered By

Molecular Biology and Genetics

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSOCIATE PROFESSOR HASAN BUĞRA ÇOBAN

Offered to

Molecular Biology and Genetics Molecular Biology and Genetics

Course Objective

To introduce industrial level cellular biosystem working principles and production kinetics

Learning Outcomes of the Course Unit

1   To understand the preparation of a general biosystem 2   To describe aeration, agitation, and mass transfer phenomena in the bioreactors 3   To be able to calculate values such as substrate consumption, production formation, and microbial accumulation data during cellular activity in the production medium 4   To introduce the principle of batch, fed-batch, and continuous bioreactors 5   To be able to optimize the biosystem conditions statistically 6   To apply the scale-up strategies from lab to industry scale

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 General cell structure and working mechanism 2 Enzyme kinetics 3 Enzyme inhibitions and immobilized enzymes 4 Batch bioreactors and sterilizations 5 Cellular growth in bioreactors and calculations 6 Cellular growth laboratory 7 Fed-batch bioreactors and working principles 8 Bioreactor optimization based on system outcomes 9 Midterm 10 Continuous bioreactors and working principles 11 Two-staged and recycled bioreactors and working principles 12 Aeration and oxygen transfer calculations in the bioreactors 13 Oxygen transfer calculation laboratory 14 Agitation kinetics in bioreactors 15 Scale up strategies in bioreactors 16 Final exam

Recomended or Required Reading

Bioprocess Engineering Basic Concepts, Shuler and Kargi, Second Edition 2002, Prentice Hall Principles of Fermentation Technology by Stanbury, Whitaker and Hall, Second Edition 2003, Butterworth Heinemann

Planned Learning Activities and Teaching Methods

Theoretical lecture with PowerPoint, problem solving related to industrial level phenomenon, and hands-on experiences in the laboratory.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.20 + MTE * 0.30 + FIN * 0.50 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.20 + MTE * 0.30 + RST * 0.50

Further Notes About Assessment Methods

None

Assessment Criteria

Theoretical and practical knowledge will be evaluated via written exams and laboratory work skills plus laboratory reports, respectively.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

bugra.coban@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Preparations before/after weekly lectures 14 6 84 Preparation for midterm exam 1 20 20 Preparation for final exam 1 20 20 Preparing assignments 1 20 20 Preparing presentations 1 30 30 Midterm 1 3 3 Midterm 1 3 3 TOTAL WORKLOAD (hours) 222

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 1 LO.2 2 2 2 LO.3 3 3 3 3 LO.4 4 4 4 LO.5 5 5 LO.6 5 5