COURSE UNIT TITLE

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR GIZEM ÇALIBAŞI KOÇAL

Offered to

Translational Oncology

Course Objective

Advances in in vitro 3D culture technologies with organoids have opened new avenues for the development of cancer models for further research. Such preclinical models are essential for more efficient translation of basic cancer research into new treatment regimens for patients with cancer. Normal tissue organoids can be grown from embryonic and adult stem cells and exhibit self-organizing capacities, embodying essential features of the organs from which they are derived. Genetic modification of organoids with gene editing technologies allows disease modeling in an environment approaching the physiological environment. In addition to all these, organoids can be grown with high efficiency from patient-derived tumor tissues. Thus, advances with organoid technology potentially allow for the development of patient-specific drug testing and individualized treatment regimens.

Learning Outcomes of the Course Unit

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Recomended or Required Reading

Francies H.E., Barthorpe A., McLaren-Douglas A., Barendt W.J., Garnett M.J. (2016) Drug Sensitivity Assays of Human Cancer Organoid Cultures. In: Turksen K. (eds) Organoids. Methods in Molecular Biology, vol 1576. Humana, New York, NY.
Tumor Organoids. edited by Shay Soker, Aleksander Skarda. Humana Press, 2017.
LeSavage, B.L., Suhar, R.A., Broguiere, N. et al. Next-generation cancer organoids. Nat. Mater. (2021).
Drost, J., Clevers, H. Organoids in cancer research. Nat Rev Cancer 18, 407 418 (2018).
Fan, H., Demirci, U. & Chen, P. Emerging organoid models: leaping forward in cancer research. J Hematol Oncol 12, 142 (2019).
Lo YH, Karlsson K, Kuo CJ. Applications of Organoids for Cancer Biology and Precision Medicine. Nat Cancer. 2020;1(8):761-773.

Planned Learning Activities and Teaching Methods

Theoretical lectures, and discussion of the topics with in-class activities (presentations and assignments)

Assessment Methods

Further Notes About Assessment Methods

None

Assessment Criteria

With homework and presentation (LO 2,3, and 6)
With exam (LO 1,2,3,4,5,6)

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gizem.calibasi@deu.edu.tr ; 0 232 412 58 01

Office Hours

Tuesday at 14:00-15:00

Work Placement(s)

None

Workload Calculation

Contribution of Learning Outcomes to Programme Outcomes