COURSE UNIT TITLE

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR YASEMIN BAŞBINAR

Offered to

Translational Oncology

Course Objective

Although mechanobiology is widely recognized as an emerging discipline, its concept was proposed more than a hundred years ago by the mathematical biologist D'Arcy Wentworth Thompson. In his 1917 book On Growth and Form (Thompson, 1992), it was envisioned that life forms would reflect physical and mathematical principles. Since then, mechanobiologists have strove to transform cell and developmental biology into the field of quantitative science and technology, accelerated by the development and application of new approaches, including virtual force theory (Putra et al.) and random positioning machines (Bradbury et al.).
Over the past three decades, the authoritative concept by Mina Bissell et al that "phenotype can dominate genotype" (Nelson and Bissell, 2006) has further emphasized the overarching role of tissue and cellular mechanisms in health and disease. Indeed, an increase in matrix stiffness may promote tissue transformation via signals from abnormal mitosis and adhesion receptors (Butcher et al., 2009; Knouse et al., 2018). However, the quantitative nature of sequence analysis in the field of genomics has almost fulfilled the promise of personalized medicine. In this post-genomic era, we envision that the cell, developmental mechanobiology, and its pathogenesis could in principle drive a new form of personalized medicine; this will emerge from the quantitative description of molecular, cell and tissue dynamics (Putra et al.)
Within the scope of this course, the importance of mechanobiology especially in the field of cancer and its reflections on the clinic will be evaluated from a translational point of view.

Learning Outcomes of the Course Unit

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Recomended or Required Reading

To be announced.

Planned Learning Activities and Teaching Methods

Assessment Methods

Further Notes About Assessment Methods

None

Assessment Criteria

With homework and presentation (LO 1,2, and 5)
With exam (LO 3,4, and 6)

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

e-posta. yasemin.baskin@deu.edu.tr ; 0 232 412 8231

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Contribution of Learning Outcomes to Programme Outcomes