COURSE UNIT TITLE

: OPTICAL IMAGING

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
RDF 5012 OPTICAL IMAGING COMPULSORY 1 2 0 5

Offered By

Radiopharmaceutical Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR GÜLGÜN OKTAY

Offered to

Radiopharmaceutical Sciences

Course Objective

The purpose of this course is to teach the optical imaging methods (Bioluminescense (BLI), Fluorescence Reflectence Imaging (FRI), Fluorescence Transillumination Imaging (FTI), Optical Tomography (OT)) and its pre-clinical applications
to give the knowledge about in vivo fluorescence imaging and instrumentation, and applications
to have theoretical knowledge about molecular probes and optic signalling molecules
to have the students do the applications in KODAK 4000MM Image Station which is already settled in Medical Biochemistry Department.

Learning Outcomes of the Course Unit

1   Have the knowledge about the principles of optical imaging instruments and methods
2   Be able to critically analyze the basic concepts of optical imaging methods
3   Be grasped the theoretical knowledge about molecular probes and optic signalling molecules
4   Synthesis: Be able to discuss the learned methods by considering different ways and be able to adapt to new situations
5   Be able to present by explicating the results of one of the applied methods

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to Optical Imaging
2 Optical Imaging Methods-1 Bioluminescense (BLI) Fluorescence Reflectence Imaging (FRI) Fluorescence Transillumination Imaging (FTI) Optical Tomography (OT)
3 Optical Imaging Methods -2 Optical Tomography (OT) - Optical coherence tomography (OCT) Diffuse optical tomography (DOT) Fluorescence molecular tomography (FMT) Thermoacoustic computed tomography (TCT)
4 In vivo Fluorescence Imaging Methods -1 Intrinsic limitations - Tissue absorption,scattering and autofluorescence - In vivo sources of optical contrast
5 In vivo Fluorescence Imaging Methods -2 Instrumentation in Fluorescence Imaging
6 In vivo Fluorescence Imaging Methods -3 Performance requirements - Spatial Resolution - Sensitivity - Quantification
7 In vivo Fluorescence Imaging Methods - 4 Applications - Neurological,Cardiovascular, Respiratory, Gastrointestinal, Immunological, Musculoskeletal, Reproductive
8 Mid-term exam
9 State-of-the-art fluorescence tomography instruments and methods
10 Moleculer Imaging Probes -1 Practice Smart probs
11 Moleculer Imaging Probes -1 Practice Activatable probes
12 Moleculer Imaging Probes -1 Practice Labelling with reactive dyes
13 Moleculer targetting
14 How to choose the right imaging modality
15 Final exam

Recomended or Required Reading

Textbook(s):
Optical Imaging ; Ralf B. Schulz and Vasilis Ntziachristos
How to Choose the Right Imaging Modality ; Fabian Kiessling, Bernd J. Pichler, and Peter Hauff
Imaging in Oncology Research Wolfgang A. Weber and Fabian Kiessling

Planned Learning Activities and Teaching Methods

This course consists of theory and practical sections. This course is given as a mini project. In theoretical section of the course, the basic principles and procedures regarding the method are given.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 FIN FINAL EXAM
4 FCGR FINAL COURSE GRADE MTE * 0.30 + ASG * 0.20 + FIN* 0.50
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.30 + ASG * 0.20 + RST* 0.50


Further Notes About Assessment Methods

None

Assessment Criteria

Comprehension, learning, analysis, comparison, applications, interactive participation

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gulgun.oktay@deu.edu.tr Telefon: 412 44 02 GSM: + 5363548774

Office Hours

Friday 12.30-13:30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 1 14
Tutorials 14 2 28
Preparations before/after weekly lectures 14 1 14
Preparation for midterm exam 1 15 15
Preparation for final exam 1 15 15
Preparing assignments 1 15 15
Preparing presentations 1 15 15
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 120

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14PO.15PO.16
LO.125
LO.225
LO.344
LO.44
LO.54

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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