COURSE UNIT TITLE

: SPECIAL TOPICS IN MOLECULAR MEDICINE

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MOT 6047 SPECIAL TOPICS IN MOLECULAR MEDICINE ELECTIVE 2 0 0 6

Offered By

Molecular Medicine

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSISTANT PROFESSOR MEHTAP YÜKSEL EĞRILMEZ

Offered to

Molecular Medicine
Molecular Medicine

Course Objective

Recent studies highlightened the molecular mechanisms of the diseases in detail. This resulted in developing new approaches to the diagnosis and treatment of the diseases. The aim of this course is to study the diseases systemically and to discuss the molecular mechanisms of diseases such as cancer, diabetes, atherosclerosis, and to analyse the molecular targets for the diagnosis and to evaluate new therapy trends.

Learning Outcomes of the Course Unit

1   Describe endothelium-microenvironment interactions and related diseases.
2   Define inflammation, cytokines, adipokines, signalling pathways and related diseases.
3   Describe inflammasomes, mechanisms and related diseases.
4   Discuss cell survival and cell death mechanisms.
5   Describe mitochondrial DNA and related diseases.
6   Define miRNAs and miRNAs in diseases.
7   Describe endoplasmic stress, unfolded protein response and related diseases.
8   Discuss exosomes and related diseases.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Endothelium -microenvironment interactions and diseases
2 Inflammation, cytokines and receptors
3 Adipokines and related diseases
4 Signaling pathways and transcription factors
5 Inflammasomes, mechanisms and related diseases
6 Cell survival and cell death- Necroptosis
7 Cell survival and cell death- Apoptosis
8 Cell survival and cell death- Ferroptosis
9 Cell survival and cell death- Autophagy
10 Mitochondrial DNA and related diseases
11 miRNAs and miRNAs in diseases
12 Endoplasmic reticulum stress, unfolded protein response and related diseases
13 Exosomes and related diseases
14 Paper discussion
15 Student presentations
16 Final Exam

Recomended or Required Reading

1. Molecular Medicine: An introduction. Jens Kurreck, Cy Aaron Stein. 2015, John Wiley & Sons Inc. Publication.
2. Biology of Disease. Eds: Ahmed N, Dawson M, Smith, Wood E, 2007, Taylor & Francis Group, New York.
3. Harper s Illustrated Biochemistry Murray, Bender, Rotham, Kennelly Rodwell and Weil, 28th Edition, 2009,McGraw Hill International Edition.
4. Textbook of Biochemistry with Clinical Correlations. Thomas M. Devlin. Seventh Edition 2011, John-Wiley& Sons Inc. Publication.
5. Functional Biochemistry in Health and Disease. Newsholme, EA and Leech. 2010, Wiley-Blackwell, Oxford.
6. Cell Survival and Cell Death. Eric H. Baehrecke, Douglas R. Green, Sally Kornbluth, Guy S. Salvesen. 2013, Cold Spring Harbor Laboratory Press.
7. Current Perspectives in microRNAs (miRNA). Ying, S. 2008, Springer.
8. Emerging Concepts of Tumor Exosome Mediated Cell-Cell Communication. Zhang, Huang-Ge. 2013, Springer.
9. MicroRNAs: From Basic Science to Disease Biology. Appasani, K. 2008, Cambridge

Planned Learning Activities and Teaching Methods

The course will be run in an integrated way-winding theory with case discussion. The methods of learning will be interactive.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 PAR PARTICIPATION
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE ASG * 0.30 +PAR * 0.30 +FIN* 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 +PAR * 0.30 +RST* 0.40


Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

The student is expected to read the resources before coming to class. In addition, he/she is expected to contribute actively to discussion, group-work and case study practices. Plagiarism of any type will result in disciplinary action.

Contact Details for the Lecturer(s)

Assist. Prof. Dr. Mehtap Yüksel Eğrilmez

Email: mehtap.yuksel@deu.edu.tr Phone: 412 2606

Office Hours

Mondays 12.30-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 30 2 60
Preparations before/after weekly lectures 30 1 30
Preparation for final exam 1 30 30
Preparing assignments 1 12 12
Preparing presentations 1 15 15
Final 1 3 3
TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14
LO.155115555555115
LO.255115555555115
LO.355115555555115
LO.455115555555115
LO.555115555555115
LO.655115555555115
LO.755115555555115
LO.855115555555115