COURSE UNIT TITLE

: MOLECULER PHARMACOLOGY

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MOT 6032 MOLECULER PHARMACOLOGY ELECTIVE 2 0 0 6

Offered By

Molecular Medicine

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR MUKADDES GÜMÜŞTEKIN

Offered to

Molecular Medicine
Molecular Medicine

Course Objective

The detailed course objectives are: to learn the general information and concepts about pharmacology and moleculer pharmacology, to have information about target molecules of drugs, like receptors, ion channels, enzymes, carrier molecules, to have information about moleculer models in drug-receptor interaction and radioligand binding methods, to have information about the mechanisms of action of drugs targeting intracellular molecules or cell components which is currently used or under development, to understand and interpret the drugs or treatment modalities which have roles in physiological and/or pathological processes and molecular structures.

Learning Outcomes of the Course Unit

1   be able to define the concepts and general information about the molecular pharmacology
2   be able to identify the target molecules of drugs
3   be able to understand the mechanisms of action of drugs at the molecular level
4   be able to evaluate and identify the effects of drugs used for diagnosis and treatment
5   be able to know and identify the molecules that mediate the adverse effects of drugs and, establish the relationship of pharmacogenetics

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to Pharmacology Definition and Basic Concepts
2 General Mechanisms of Action of Drugs
3 Introduction to Molecular Pharmacology Definition and Basic Concepts
4 What are the target molecules of drugs Receptors, Ion Channels, Enzymes, Carrier Molecules
5 Intracellular Signal Transduction and Drug Target Molecules-I
6 Intracellular Signal Transduction and Drug Target Molecules-II
7 Molecular Models of Drug-Receptor Interaction-I Radioligand Binding Methods
8 Molecular Models of Drug-Receptor Interaction-II Others
9 Structure-Activity Relationship
10 Drugs Affecting the Cell Cycle
11 Drugs Affecting Apoptosis
12 Pharmacogenetic and Pharmacogenomics
13 Gene Therapy
14 Biotechnology products
15 Side Effects of Drugs and Mechanisms of Side Effects
16 Final exam

Recomended or Required Reading

Textbook(s):
1. Goodman & Gilman's The Pharmacological Basis of Therapeutics , 2012
2. Rang and Dale s Pharmacology, 7th. Edition, 2011
3. Medicinal Chemistry, Gareth Thomas, 2nd. Edition, 2007
4. Basic and Clinical Pharmacology. B.Katzung. Appleton & Lange. 11th ed. 2007.
5. The Cell: A Molecular Approach, Geoffrey M. Cooper and Robert E. Hausman, 5th Edition, 2009
6. Pharmacology of Neurotransmitter Release, Boehm, S. Springer, 2008
7. Pharmacology Primer, 3rd ed. / Terry Kenakin. 2009.
8. Pharmacology: Principles and practice. Bachmann, Kenneth A. Elsevier/Academic Press, 2009

Supplementary Book(s):
1. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. S. Oğuz Kayaalp. Pelikan Yayıncılık. 12. Baskı, 2009

Planned Learning Activities and Teaching Methods

Assessment Methods

To be announced!


Further Notes About Assessment Methods

Students are expected to make power point presentation related a subject from molecular pharmacology.

Assessment Criteria

Students achievement will be measured by passing the final exam and making power point presentation related to a subject from course program.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gumustek@deu.edu.tr, telephone number: 4123906

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparation before/after weekly lectures 15 5 75
Preparation for Final Exam 1 39 39
Preparing Presentations 1 20 20
Final 1 1 1
TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14
LO.155444544444223
LO.255554545443223
LO.355554555444223
LO.453443534545223
LO.555354554545223