COURSE UNIT TITLE

: CELL SIGNAL TRANSDUCTION AND DEATH PATHWAYS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BIO 6071 CELL SIGNAL TRANSDUCTION AND DEATH PATHWAYS ELECTIVE 3 0 0 5

Offered By

Biochemistry

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR AYŞE SEMRA KOÇTÜRK

Offered to

Biochemistry

Course Objective

The purpose of the course is to teach postgraduate students on the mechanisms of intracellular signal transduction and cell death pathways that determine the fate of a cell. For this purpose, the course begins with the cell cycle lecture that controls cell proliferation and death, followed by cell signal transduction pathways that can be activated by various external and internal factors, and ended with different cell death mechanisms that lead the cell to death. At the end of the course, an increase in the query and research ability on therapeutic approaches for degenerative disease is targeted.

Learning Outcomes of the Course Unit

1   LO1-Has basic knowledge of cell biology to understand cell signaling mechanisms (PO1, PO2).
2   LO2- Associates and presents intracellular signal transduction and cell death mechanisms(PO5;PO6,PO7,PO8,PO9,PO10).
3   LO3- Access and use information and databases related to the course subject (PO8,PO9).
4   LO4- Can understand cellular mechanisms underlying diseases with the knowledge gained from the course (PO6, PO7, PO9).
5   LO5-Has the ability to plan a research for degenerative diseases at the molecular level (PO9, PO10).

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Cell cycle, its control and its relationship with cell death.
2 G-protein coupled receptor mediated signal transduction
3 Serine Kinase receptors signal transduction pathways: TGF-b / SMAD3 / SMAD4 .
4 Cytokine receptors: JAK / STAT signal transduction.
5 Tyrosine kinase receptors and the Ras / MAP Kinase signaling pathway
6 PI3-Kinase and PTEN mediated signal transmission
7 Ubiquitins and signaling pathways that control protein degradation-I: WNT / HEDGEHOG / NF-KB.
8 Signaling pathways controlling that control protein degradation-II: NOTCH / DELTA / SREBP.
9 Mid Term Exam
10 Cell Death and Signaling Pathways-I: Apoptosis, Necroptosis
11 Cell Death and signaling pathways-II: Autophagy, Ferroptosis
12 Cell Death and signaling pathways-III: Entosis, Paraptosis, Partanatosis, Mitoptosis, Pyroptosis.
13 Altered signal transduction pathways in cancer cells and their relationship with cell death pathways-I: EGFR, MAPK / Erk, PI3Kinase / Akt / mTOR, cMyc, HIF-1, P53, NF-Kb.
14 Altered signal transduction pathways in cancer cells and their relationship with cell death pathways -II: JAK / STAT, TGF-b, WNT, NOTCH
15 ER stress, Misfolded protein stress and mitochondria mediated signal transduction pathways in aging and neurodegeneration.
16 Assigment Presentations and Evaluation

Recomended or Required Reading

1. Molecular Cell Biology 8th Edition, Editors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, ISBN-13: 978-1-4641-8339-3, 2016, Printed in the United States of America by W. H. Freeman and Company. One New York Plaza, Suite 4500, New York, NY 10004-1562
2. Cell Death Mechanism and Disease, Editor: Hao Wu, ISBN 978-1-4614-9301-3, 2014, Springer New York Heidelberg Dordrecht London.
3. Cell Death Signaling in Cancer Biology and Treatment, Editor, Daniel E. Johnson, ISBN 978-1-4614-5846-3, Springer New York Heidelberg Dordrecht London.

Planned Learning Activities and Teaching Methods

Providing learning by giving theoretical lectures and presentation assigment. Developing prospective research planning skills in line with the information gained during presentation preparation.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 FIN FINAL EXAM
4 FCGR FINAL COURSE GRADE MTE * 0.30 + ASG * 0.20 + FIN* 0.50
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.30 + ASG * 0.20 + RST* 0.50


Further Notes About Assessment Methods

None

Assessment Criteria

1. Theoretical knowledge of cellular signaling pathways and cell death mechanisms will be evaluated with midterm, final exam and oral presentation (PÇ1, PÇ2;PÇ5,PÇ6,PÇ7,PÇ9,PÇ10).
2. The ability to apply the information learned, the ability to access and interpret the necessary databases will be evaluated with assigment / presentation (PÇ8, PÇ9).

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

semra.kocturk@deu.edu.tr

Office Hours

on Wendnesday at: 13:30-14:30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 3 45
Preparations before/after weekly lectures 15 3 45
Preparation for midterm exam 1 12 12
Preparation for final exam 1 12 12
Preparing presentations 1 12 12
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 130

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13
LO.155
LO.2555555
LO.355
LO.455
LO.555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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