COURSE UNIT TITLE

: NEUROCHEMISTRY

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BIO 6069 NEUROCHEMISTRY ELECTIVE 4 2 0 9

Offered By

Biochemistry

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR PINAR AKAN

Offered to

Biochemistry

Course Objective

The aim of this course is to discuss the biochemical structure of CNS and its roles in neuronal diseases, to learn brain metabolism and to introduce neuro-endocrinology.
In the practical related to the course, the following applications will be conducted: CSF biochemistry, cell counting, CSF IgG index, CSF oligoclonal band analysis and to interpret the other routine biochemical markers in CNS disorders.

Learning Outcomes of the Course Unit

1   Understand, at the introductory level, neurochemistry which is one of the subject areas of biochemistry
2   Have expertise in the theoretical basis of advance laboratory techniques in neuro-chemical research.
3   Have the knowledge on biochemical markers of neuronal diseases and interpretation the test s results,
4   Present neuronal tissue characteristics including biochemical structure, brain metabolism and their clinical aspects.
5   Demonstrate skills in laboratory work related to neuronal damage markers (Ex: Enzyme kinetics, enzyme activity measurement, inhibition).

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to neurochemistry
2 Structural, functional and molecular neurochemistry Small group activity
3 Biochemical structure of brain
4 CSF and blood-brain barier
5 Neural Tissue Cell Types and Metabolism
6 Myelin synthesis and myelin biochemistry
7 Neurotransmision I Neurotransmitters
8 Neurotransmision II Neuromodulators, neuropeptides
9 Introduction to Neuroendocrinology Small Group Activity
10 Central nervous system and oxidative stress
11 Biomarkers in CNS Disease I
12 LABORATORY PRACTICAL: CSF oligoclonal band Index
13 Biomarkers in CNS Disease II
14 LABORATORY PRACTICAL: CSF analysis
15 Biochemical Hypothesis in Physciatric Disease

Recomended or Required Reading

1. Basic Neurochemistry Molecular Cellular and Medical Aspects ,7th Ed.,2006 USA
2. The Biochemical Basis of Neuropharmacology 8th Ed.2003,USA.
3. Culturing Nevre Cells,2nd Ed. 1998,MIT ,USA.

Planned Learning Activities and Teaching Methods

The course will be run in an integrated way-winding theory with case discussion and laboratory practicals. The methods of learning will be interactive.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PRF * 0.40 + FIN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PRF * 0.40 + FCGR*0.60


Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

The student is expected to read the resources before coming to class. In addition, he/she is expected to contribute actively to discussion, group-work and practicals. Attending in at least 70 percent of lectures and in at least 80 percent of practicals are mandatory. Plagiarism of any type will result in disciplinary action.

Contact Details for the Lecturer(s)

Pınar Akan:
Phone: 412 44 11/ 25 52
GSM: + 536 341 51 30

Office Hours

Every day, 12.30-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 3 45
Tutorials 16 5 80
Preparations before/after weekly lectures 5 2 10
Preparation for final exam 1 40 40
Preparation for quiz etc. 1 30 30
Preparing presentations 1 10 10
Preparing assignments 1 10 10
Practice in Legal Institutions 1 8 8
Final 1 2 2
Quiz etc. 1 2 2
TOTAL WORKLOAD (hours) 237

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13
LO.145
LO.24
LO.3453
LO.445543
LO.545543435