COURSE UNIT TITLE

: BASIC BIOCHEMISTRY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BIO 5007 BASIC BIOCHEMISTRY ELECTIVE 4 0 0 4

Offered By

Biochemistry

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR ALIRIZA ŞIŞMAN

Offered to

Molecular Medicine
Laboratory Medicine
Biochemistry
TRANSLATIONAL MEDICINE

Course Objective

The main aims of the course are to teach the biomolecules playing roles in living organisms and their functions. The metabolic pathways and their regulations are also included by the course

Learning Outcomes of the Course Unit

1   learn the feature of biochemical molecules
2   Learn nucleic acids, molecular characteristics and the synthesis of these molecules
3   Understand the basic features of amino acids, synthesis and degradation of these molecules , and the structural features of proteins and enzymes and theirs functions
4   Learn types and structures of carbohydrates
5   Understand molecular and functional properties of lipids
6   Learn bioenergetics and basic terms related to bioenergetics
7   Learn the metabolic pathways of carbohydrates, lipids and amino acids, in which energy and intermediate substances are produced and the regulation of these pathways

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Amino acids; the structure and classification. Biosynthesis of amino acids. Peptides and proteins; structural levels and denaturation.
2 Enzymes, enzyme kinetics and coenzymes. Nucleotides & nucleic acids. Replication
3 Transcription & RNA processing. Translation, posttranslational modifications, folding and protein targeting
4 Regulation of gene expression Biosynthesis and degradation of nucleotides.
5 Bioenergetics and the laws of thermodynamics. Phosphoryl group transfers and ATP Biological redox reactions
6 Mono- , di- and polysaccharides. Glycolysis and feeder pathways for glycolysis. Pentose phosphate pathway
7 Gluconeogenesis Coordinated regulation of glycolysis and gluconeogenesis. Glycogen metabolism. Coordinated regulation of glycogen synthesis and breakdown.
8 Classification of lipids. The structure of triacylglycerols and phospholipids Biosynthesis of triacylglycerols and phospholipids
9 Biosynthesis of cholesterol, steroids and isoprenoids. Biosynthesis of fatty acids and eicosanoids
10 Oxidation of fatty acids and ketogenesis. Formation of acetylCoA The TCA cycle Regulation of the cycle.
11 Membrane structure and membrane dynamics. Transport across membranes The amino group metabolism of amino acids. Urea cycle
12 The pathways for amino acid degradation Electron transport chain Oxidative phosphorylation and ATP synthesis.
13 The integration and regulation of fuel metabolism. Proteoglycans, glycoproteins, glycolipids and glycosaminoglycans and their biological functions
14 Hormones; structures & functions Intracellular signaling pathways

Recomended or Required Reading

Marks Basic Medical Biochemistry, A Clinical Approach. Michael Lieberman, Allan D. Marks, Third Edition, Lippincott Williams & Wilkins, 2009.
Fundamentals of Biochemistry, Life at the Molecular Level. Donald Voet, Judith G. Voet & Charlotte W. Pratt. Second Edition. John Wiley & Sons, Inc, 2006.
Insan Biyokimyası. Taner Onat, Kaya Emerk, Eser Y. Sözmen. Palme Yayıncılık, Ankara, 2002. (Turkish)

Planned Learning Activities and Teaching Methods

Main method is teacher s presentation. Some presentations may be prepared and presented by students upon request of teachers. Students are expected to read the topic before coming to lecture. A theorical report on a special topic must be prepared by students.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE MTE * 0.50 + FIN* 0.50
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.50 + RST* 0.50


Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

The student is expected to read the resources before coming to class.

Contact Details for the Lecturer(s)

Phone: + 90 232 412 44 21
e-mail: halil.resmi@deu.edu.tr

Office Hours

Mondays 12.30-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 4 60
Preparations before/after weekly lectures 2 2 4
Preparation for midterm exam 2 7 14
Preparation for final exam 1 14 14
Final 1 3 3
Midterm 2 3 6
TOTAL WORKLOAD (hours) 101

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9
LO.14
LO.23
LO.33
LO.43
LO.53
LO.63
LO.73

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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