COURSE UNIT TITLE

: EPITHELIAL MESENCHYMAL TRANSITION, RESEARCH AND APPLICATIONS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ELECTIVE

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSISTANT PROFESSOR ASLI SADE MEMIŞOĞLU

Offered to

Ph.D. in Biotechnology
Ph.D. in Biotechnology
BIOTECHNOLOGY

Course Objective

To understand the molecular mechanisms of the epithelial mesenchymal transition process, its role in normal and disease processes, its effects on tumor progression and to interpret research methods by following the developments in the field.

Learning Outcomes of the Course Unit

1   To evaluate epithelial mesenchymal transition in normal and disease processes.
2   To have information about the role of epithelial mesenchymal transition in metastasis
3   Familiarity with experimental approaches used to study epithelial mesenchymal transition
4   To critically evaluate the design and results of scientific literature on epithelial mesenchymal transition.
5   To be able to independently write and present critiques of scientific articles on epithelial mesenchymal transition

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to EMT
2 A Spectrum of Cell States During the Epithelial-to-Mesenchymal Transition
3 Epithelial-Mesenchymal Transition in embryos and wound healing
4 Partial EMT/MET: An Army of One
5 EMT in cancer and fibrosis
6 EMT plasticity and metastatic colonization
7 Article discussion 1 Mid homework
8 Circulating Tumor Cells, tumor microenvironment and cancer stem cells
9 Extrinsic and intrinsic signals promoting EMT and MET
10 Discovery of EMT-related biomarkers in disease development
11 Current treatment methods targeting EMT and their advantages-disadvantages
12 Development and future of nanotechnology and targeted therapies
13 Article discussion 2
14 Final project

Recomended or Required Reading

Main source: Kyra Campbell, Eric Theveneau. (2021). The Epithelial-to Mesenchymal Transition, Methods and Protocols. Humana New York, NY
Subsidiary sources:
Mohit Kumar Jolly Toni Celia-Terrassa. (2020). Epithelial-Mesenchymal Plasticity in Cancer Metastasis Molecular Reprogramming, Cellular Adaptation, and Clinical Implications. MDPI, Switzerland.
Weinberg, R. A. (2014). The Biology of Cancer. 2nd edition. Garland Science, Taylor and Francis Group, New York.
Ders sırasında verilecek makaleler ve sunumlar

Planned Learning Activities and Teaching Methods

Presentation, lecture, article discussion, question and answer technique

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 PAR PARTICIPATION
3 ASG ASSIGNMENT
4 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.40 + PAR * 0.10 + ASG * 0.50


Further Notes About Assessment Methods

Homework: Mid-semester research homework questions.
Project: End-of-semester article review homework.
Participation: Discussion of two articles during the semester.

Assessment Criteria

Students will be evaluated with midterm essay discussion studies, mid-term homework and end-of-semester project.

Language of Instruction

English

Course Policies and Rules

The students have to continue to the class as 70% in a term.

Contact Details for the Lecturer(s)

asli.memisoglu@deu.edu.tr

Office Hours

Announced during the semester

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
TOTAL WORKLOAD (hours) 0

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6
LO.1533
LO.2533
LO.3545555
LO.4555453
LO.5554453

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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