COURSE UNIT TITLE

: MEDICAL BIOLOGY AND GENETICS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TPF 1004 MEDICAL BIOLOGY AND GENETICS COMPULSORY 2 0 0 4

Offered By

Dentist

Level of Course Unit

First Cycle Programmes (Bachelor's Degree)

Course Coordinator

PROFESSOR DOCTOR SULTAN CINGÖZ

Offered to

Dentist

Course Objective


The aim of this course is Basic rules of Medical Biology and Genetics, living chemistry, biological molecules, their structures and functions, cell structure and to teach organelles, diseases related to these organelles, DNA replication, transcription and RNA
processing, translation and posttranslational modifications, DNA mutations and repair mechanisms. Cell division and control, cancer genetics, Mendelian inheritance in humans, non-Mendelian inheritance patterns, cellular energy and metabolism, mitochondrial genome, mitochondrial diseases, chromosomal abnormalities, cytogenetics, molecular genetics, information on human genetics, genetic diseases and diversity, bacterial and viral viral genetics, DNA technologies and to ensure that all this information can be used in the field of Dentistry.

Learning Outcomes of the Course Unit

1   Outlines the structure and biochemical features of nucleic acids.
2   Knows basic medical concepts can relate the concepts
3   Knows the potential of biological molecules to be used in dentistry and can follow the latest on the subject.
4   Describe in detail the processes of replication, transcription, post-transcriptional RNA processing and translation in eukaryotes and prokaryotes.
5   Knows the structure, types and organelles of cells. Recognizes diseases related to organelles and relates them to formation mechanisms.
6   Describes the processes that transforms a polypeptide chain in to a functional protein (post-translational modifications, protein folding, protein targeting, protein degradation ect.)
7   Knows and repeats the genetic regulation mechanisms in prokaryotes and eukaryotes.
8   Outlines genetic recombination mechanisms.
9   Knows Mendelian genetics in humans and establishes a situation relationship.
10   Knows inheritance patterns that do not comply with Mendelian rules, relates molecular mechanisms of related diseases.
11   Recognizes chromosomal diseases and explains the formation mechanism
12   Relates cancer and its molecular mechanisms
13   Describes the cell skeleton and its role in cell motility & mobility
14   Explains features of the cell surface
16   Knows the factors that cause diseases and the genetics of these factors
17   Knows human genetics
18   Identify, correctly hypothesize and solve problems in medical biology and genetics
19   Able to work in an interdisciplinary team

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to Medical Biology. Related Sciences, Definition of the cell, its history. Types of light and electron microscopy
2 Primitive and true nucleated cells, general characteristics of the cell. Virus and bacteria
3 Organic and inorganic compounds synthesized and used by the cell. Structure of nucleic acids
4 Nucleus, Nucleolus and functional structures of chromosomes
5 Cell membrane, molecular structure and cell membrane differentiation. Cytoplasmic organelles, endoplasmic reticulum and its function
6 Ribosomes, Golgi complex, Mitochondria, Lysosomes
7 Centrioles, Microtubilis and Cilia
8 Cell division
9 Structure and properties of membrane receptors (Cell surface and attachment sites)
10 Molecular basis of intercellular communication
11 Abnormal cell differentiation, cancer cells formation mechanisms
12 Molecular biology of cancer cells
13 midterm exam
14 Structure of Genetic Material
15 DNA Replication
16 Transcription and RNA processing, Regulation of gene expression
17 Genetic Code, Translation
18 Mitochondrial Genome and mitochondrial diseases
19 Basic Genetics, Mendelian Laws
20 Mutual Effects of Genes and Deviation in Mendelian Ratios (inheritance patterns that do not follow Mendelian rules
21 Organization of Eukaryotic Genomes
22 Cytogenetics, Basic Chromosome Abnormalities
23 DNA mutations and repair mechanisms, Mutagens and teratogens
24 Human Genetics. of Medical Genetics developmental characteristics, disease genetics relationship. Mendelian principles expansion in human genetics
25 A-X-linked inheritance a) Recessive b) Dominant B- Y Chromosome inheritance multifactorial
26 Overview of genetic diseases
27 Single Gene Diseases and DNA diagnosis
28 Final Exam

Recomended or Required Reading


1. Hücre, Moleküler Yaklaşım, (The Cell, A Molecular Approach 2nd edition Geoffey M. Cooper, Robert E. Hausman.) Çeviri Editörleri: Meral Sakızlı, Neşe Atabey. Izmir Tıp Kitabevi, ISBN: 9944-5148-0-2, Ankara 2006 .
2. Hücrenin Moleküler Biyolojisi, (Molecular Biology of the Cell,4th Edition. Ed. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishers) Çeviri Editörleri: Nur Buyru, Nejat Dalay, Meral Özgüç, Mehmet Öztürk, Meral Sakızlı, ISBN: 978-9944-252-22-5, TÜBA ders kitapları, 2008
3. Thompson & Thompson Tıbbi Genetik - Mehmet Alikaşifoğlu, Güneş Tıp Kitabevleri

Planned Learning Activities and Teaching Methods

Presentation: Basic theoretical information will be given as a presentation.
Projector, computer, animation etc. face to face with support
with the participation of the student in the form of lecture, question-answer
will be executed

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 VZ1 1.Vize
2 VZ2 2.Vize
3 VOR Vize Ortalaması roundVZ1 * 0.50 + VZ2 * 0.50,0
4 FN Final
5 FSB Final Sonu Başarı Notu roundVOR * 0.40 + FN * 0.60,0
6 BUT Bütünleme
7 BSB Bütünleme Sonu Başarı Notu roundVOR * 0.40 + BUT * 0.60,0


Further Notes About Assessment Methods

None

Assessment Criteria

1. The accuracy of the answers given to the questions asked in the written midterm exam is the evaluation criterion.
2. Midterm exam success rate 60%
3.Final success rate 40%
3. Attendance and in-class participation are evaluation criteria.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Tel: 0232 412 4604 E-posta: sultan.cingoz@deu.edu.tr

Office Hours

Monday 13:30-15:10

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 28 2 56
Preparation before/after weekly lectures 10 3 30
Preparation for midterm exam 1 10 10
Preparation for final exam 1 10 10
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 110

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10
LO.134
LO.234
LO.333
LO.433
LO.533
LO.633
LO.733
LO.833
LO.933
LO.1033
LO.1133
LO.1233
LO.1333
LO.1433
LO.1533
LO.1633
LO.1733
LO.1834

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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