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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS KID 6009 MUSCULOSKELETAL SYSTEM BıOCHEMıSTRY AND METABOLıSM ELECTIVE 3 0 0 9

Offered By

Musculoskeletal Tissue Engineering

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR ALIRIZA ŞIŞMAN

Offered to

Musculoskeletal Tissue Engineering

Course Objective

To describe methods used in application of human biochemistry. To explain cell and general biochemistry. To use newly developing technologies in biochemistry, considering ethical values.

Learning Outcomes of the Course Unit

1   To get information about human biochemistry. 2   To understand modern techniques related to the issue by using knowledge of human biochemistry and acquisition of knowledge about applications at human body. 3   To have skills on to able to analyze processes about musculoskeletal by integrating knowledge acquired both in course and in literature. 4   To become skillful at working individual by short quizzes made regularly. 5   To become skillful at teamwork by duties given regularly.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 1. Structure and functions of cell membranes and organelles 11. Biochemical basis of muscle diseases and muscle biomarkers 2 2. Biochemical macromolecules (Nucleic acids, carbohydrates, lipids and proteins) 12. Bone structure and biochemistry 3 3. Water, pH and Buffer Concepts 13. Biochemical basis of bone diseases and bone biomarkers 4 4. Biochemical basis of apoptosis, growth and aging 14. Structure and function of cartilage, meniscus, tendon, joint and synovium 5 5. Enzymology: General concept, enzyme kinetics and clinical significance 6 6. Neuromuscular junction and signal transduction 7 7. Midterm 8 8. Connective tissue and extracellular matrix biochemistry 9 9. Muscle tissue: Fibrillar structure and contraction mechanism 10 10. Basic metabolic pathways of muscle tissue

Recomended or Required Reading

Nelson, David L. Lehninger Principles Of Biochemistry. New York : W.H. Freeman, 2008 Harvey, Richard A., Ph. D. Lippincott's Illustrated Reviews: Biochemistry. Philadelphia :Wolters Kluwer Health, 2011 Harper's Illustrated Biochemistry, Thirtieth Edition Copyright © 2015 by The McGraw-Hill Education

Planned Learning Activities and Teaching Methods

interactive presentation Homework Project

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 MTE MIDTERM EXAM 2 FIN FINAL EXAM 3 FCG FINAL COURSE GRADE MTE * 0.40 + FIN* 0.60 4 RST RESIT 5 FCGR FINAL COURSE GRADE MTE * 0.40 + RST* 0.60

Further Notes About Assessment Methods

None

Assessment Criteria

The exam success average must be 75 or above.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Prof.Dr. Alirıza ŞIŞMAN aliriza.sisman@deu.edu.tr

Office Hours

Weekday working hours.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 3 15 45 Tutorials 3 15 45 Preparations before/after weekly lectures 4 20 80 Final 2 15 30 Midterm 2 15 30 TOTAL WORKLOAD (hours) 230

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 LO.1 5 LO.2 4 LO.3 4 LO.4 5 4 LO.5 4 5