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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BST 6010 BIOENGINNERING STEM CELL MICROENVIRONMENT ELECTIVE 3 0 0 12

Offered By

Biomedicine and Health Technologies

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR SINAN GÜVEN

Offered to

Biomedicine and Health Technologies

Course Objective

To gain a thorough understanding of the stem cell microenvironment and interpret the bioengineering approach to design in vivo and in vitro cellular niches.

Learning Outcomes of the Course Unit

1   Familiarity with stem cells 2   Understanding the mechanotransduction in cells 3   Identification of biomaterials used in direct cell contact 4   Learn cell-cell interactions 5   Learn cell-material interaction 6   Identify complex hierarchical tissue architecture 7   Familiarity with bioengineering methods 8   Identify 3D cell culture methods 9   Understand the differentiation and fate decision process in stem cells 10   Presentation of research findings

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Tissue architectures 2 Biomaterials - I 3 Biomaterials - II 4 In vitro 2D cellular environments 5 In vitro 3D cellular environments 6 Cells and Stem cells - I 7 Cells and Stem cells - II 8 Midterm 9 Gases in cellular microenvironment 10 Material stiffness 11 Dynamic forces on cellular microenvironment 12 Cell - cell interactions 13 Vascularization in cellular microenvironment 14 Controlled release in cellular microenvironment 15 Assignment Presentations 16 Final Exam

Recomended or Required Reading

Textbook(s): Cells, Forces, and the Microenvironment by Charles M. Cuerrier and Andrew E. Pelling, Pan Stanford Publishing, 2015 ISBN 978-981-4613-37-8 (eBook) Review articles

Planned Learning Activities and Teaching Methods

Oral presentation, literature search and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 MTE MIDTERM EXAM 2 FIN FINAL EXAM 3 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.50 + FIN *0.50 4 RST RESIT 5 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.50 + RST * 0.50

Further Notes About Assessment Methods

None

Assessment Criteria

Theoretical knowledge will be evaluated by exam

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

sinan.guven@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Preparations before/after weekly lectures 14 8 112 Preparation for midterm exam 1 10 10 Preparation for final exam 1 25 25 Preparing assignments 3 20 60 Preparing presentations 2 25 50 Final 1 3 3 Midterm 1 2 2 TOTAL WORKLOAD (hours) 304

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 5 5 5 LO.2 5 5 LO.3 5 5 LO.4 5 5 LO.5 5 5 LO.6 5 5 LO.7 5 5 LO.8 LO.9 LO.10 5