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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS MBG 6130 STEM CELLS ELECTIVE 3 0 0 12

Offered By

Molecular Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR SINAN GÜVEN

Offered to

Molecular Biology and Genetics Molecular Biology and Genetics

Course Objective

To be able to explain the biology of stem cells and recognise the differences between stem cells and to discuss the principles and methods of stem cell based therapies.

Learning Outcomes of the Course Unit

1   To define common features of stem cells, to explain types of stem cells, to describe differences between types of stem cells 2   To explain mechanisms with respect to stem cell biology such as differentiation, direct differentiation, self renewal, plasticity, asymmetric division, potential,.. 3   To define therapeutical and reproductive cloning 4   To discuss common features and potential use of embryonic stem cells (ESC) and to learn how to produce ESC lines 5   To determine common features and types of adult stem cells (ASC) and to insight medical use of ASC 6   To understand genetic and epigenetic mechanisms behind reprogramming of fully differentiated cells and to learn common features and potential use of induced pluripotent stem cells (iPSC) and to learn how to produce iPSC cell lines and what are the limitations of technology 7   To discuss biomaterials and stem cells in regenerative medicine 8   To learn regulations for cell based therapies

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Definition of stem cells 2 Embryonic stem cells 3 Mesenchymal stem cells 4 Hematological stem cells 5 Tissue specific stem cells 6 Induced pluripotent stem cell (iPSC) 7 iPSC methods 8 Differentiation 9 Characterisation 10 MIDTERM 11 Treatment with stem cells 12 Treatment with stem cells 13 Ethics in stem cell research 14 Disease modelling with iPSC 15 Drug screening with iPSC 16 Final Exam

Recomended or Required Reading

Textbook(s): Alberts, et al. Molecular Biology of the Cell, Fifth ed., Garland Sciences. Supplementary: Review and research articles published in the journals such as: Cell Stem Cell, Science, Cell, Nature, Nature Cell Biology, Regenerative Medicine, Stem Cells and Development, PNAS, Trends in Cell Biology..etc URL: http://www.stembook.org/

Planned Learning Activities and Teaching Methods

Theoretical lectures with PowerPoint presentation and assignment presentations by students

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

esra.erdal@deu.edu.tr +90 232 4126506

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 15 2 30 Tutorials 15 2 30 Preparations before/after weekly lectures 15 4 60 Preparation for midterm exam 1 15 15 Preparation for final exam 1 25 25 Preparing assignments 1 30 30 Preparing assignments 1 40 40 Preparing presentations 15 5 75 Final 1 2 2 Midterm 1 3 3 TOTAL WORKLOAD (hours) 310

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 2 LO.2 2 LO.3 2 LO.4 2 LO.5 2 LO.6 2 LO.7 2 LO.8 2