COURSE UNIT TITLE

: EPIGENETICS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MBG 6120 EPIGENETICS ELECTIVE 3 0 0 12

Offered By

Molecular Biology and Genetics

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR HANI ALOTAIBI

Offered to

Molecular Biology and Genetics
Molecular Biology and Genetics

Course Objective

The objective of this course is to provide students with a solid foundation in both the principles of epigenetics and experimental research by emphasizing the use of primary research articles and focusing on developing analytical scientific reading and writing skills to focus on the current questions in epigenetics and how they are being addressed experimentally.

Learning Outcomes of the Course Unit

1   Understand the differences between Mendelian and epigenetic inheritance
2   Understand DNA methylation regulates gene expression
3   Understand how chromatin modifications and remodeling regulate gene expression
4   Understand the role of non-coding RNAs in epigenetic regulation
5   Understand how epigenetic modifications are propagated
6   Understand the role of epigenetics in disease

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to epigenetics, basic concept, overview and brief history of the field
2 Epigenetic modifications and gene expression: DNA methylation
3 Epigenetic modifications and gene expression: Histone modifications
4 Non-coding RNAs in Epigenetics
5 Linking epigenetic modifications to chromatin remodeling and transcription
6 Model animal systems for studying epigenetic regulation
7 Studying multiple layers of epigenetic regulation; genome-wide analysis of epigenetic marks
8 Midterm Exam
9 Imprinting
10 X inactivation
11 Epigenetic programming in cell renewal and pluripotency
12 Epigenetics in disease I: Imprinting disorders, Rett syndrome, ICF syndrome, etc
13 Epigenetics in disease II: Epigenetics and the brain
14 Cancer Epigenetics
15 Epigenetics in drug discovery
16 Final exam

Recomended or Required Reading

Current literature

Planned Learning Activities and Teaching Methods

Current literature

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 MTE MIDTERM EXAM
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40


Further Notes About Assessment Methods

If needed, other assessment methods can be added to the table given below.

Assessment Criteria

Optional, if the instructor needs to add some explanation or further note, this column can be selected from the DEBIS menu.

Language of Instruction

English

Course Policies and Rules

Optional, if the instructor needs to add some explanation or further note, this column can be selected from the DEBIS menu.

Contact Details for the Lecturer(s)

Contact Details for the Instructor:
hani.alotaibi@deu.edu.tr , tel 26570

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 3 42
Preparations before/after weekly lectures 14 5 70
Preparation for midterm exam 1 15 15
Preparation for final exam 1 20 20
Preparing presentations 2 15 30
Preparing Group Assigments 2 30 60
Preparing Individual assignments 2 20 40
Final 1 10 10
Midterm 1 5 5
TOTAL WORKLOAD (hours) 292

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8
LO.14
LO.24
LO.34
LO.44
LO.53
LO.63

CONTACT INFORMATION
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Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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