COURSE UNIT TITLE

: UN INTRODUCTION TO PRODUCTION OF RECOMBINANT PROTEIN-BASED PHARMACEUTICALS FOR PHARMACEUTICALSCANCER THERAPY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 5025 UN INTRODUCTION TO PRODUCTION OF RECOMBINANT PROTEIN-BASED PHARMACEUTICALS FOR PHARMACEUTICALSCANCER THERAPY ELECTIVE 3 0 0 6

Offered By

Translational Oncology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSOCIATE PROFESSOR MELTEM ALPER

Offered to

Translational Oncology

Course Objective

The aim of the course to teach fundamentals of molecular cloning, recombinant protein production, and purification. To have information on the production and features of recombinant protein-based cancer pharmaceuticals.

Learning Outcomes of the Course Unit

1   LO1. Be able to learn recombinant DNA technology.
2   LO2. Be able to learn fundamentals of molecular cloning.
3   LO3. Be able to learn production of recombinant proteins in different host systems and purification methods.
4   LO4. Be able to learn the production of recombinant immunotherapeutics that used in cancer therapy.
5   LO5. Be able to learn the current recombinant immunotherapeutics that used in cancer therapy

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to recombinant DNA technology Production of recombinant immunotherapeutics for cancer therapy-Monoclonal Antibodies
2 Basic components of the gene cloning (enzymes, vectors and host systems)-1 Production of recombinant immunotherapeutics for cancer therapy-Immunotoxins
3 Basic components of the gene cloning (enzymes, vectors and host systems)-2 Production of recombinant immunotherapeutics for cancer therapy-Fusion proteins
4 Gene cloning strategies-1 Current literature-1
5 Gene cloning strategies-2 Current literature-1
6 Host specific production of recombinant proteins-1
7 Host specific production of recombinant proteins-2
8 Purification strategies of recombinant proteins-1
9 Purification strategies of recombinant proteins-2
10 Production of recombinant immunotherapeutics for cancer therapy- Cytokines

Recomended or Required Reading

1-DNA Cloning and DNA Analysis, 8th Edition,T.A Brown
2-Molecular Cloning, A Laboratory Manual, 4th Edition, www.molecularcloning.org Cold Spring Harbor Protocols
3-Pharmaceutical Biotechnology: Fundamentals and Applications, Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm, Springer International Publishing,5th Edition
4-Immunotherapy in Translational Cancer Research, Laurence J. N. Cooper, Elizabeth A. Mittendorf, Judy Moyes, Sabitha Prabhakaran, Wiley-Blackwell
5-Cancer Immunology and Immunotherapy, Wolf H. Fridman, Jérome Galon (auth.), Glenn Dranoff (eds.) Springer-Verlag Berlin Heidelberg.

Planned Learning Activities and Teaching Methods

Theoretical lectures, reinforcement and discussion of the subjects with in-class activities (presentations and assignments),discussion of the current literature.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PRF * 0.40+ FIN* 0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE PRF * 0.40+ RST* 0.60


Further Notes About Assessment Methods

None

Assessment Criteria

Assessment with homework and PRESENTATION (Learning outcome 4 and 5)
Assessment with the exam (Learning outcome1,2,3 4 and, 5)

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

meltem.alper@deu.edu.tr

Office Hours

Thursday 13.00-15.00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 3 45
Preparations before/after weekly lectures 15 2 30
Preparation for final exam 5 5 25
Preparing assignments 5 3 15
Preparing presentations 5 7 35
Final 1 2 2
TOTAL WORKLOAD (hours) 152

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.155
LO.255
LO.3555
LO.4555
LO.555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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