COURSE UNIT TITLE

: TUMOR ANGIOGENESIS AND VASCULATION

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 6026 TUMOR ANGIOGENESIS AND VASCULATION ELECTIVE 3 0 0 6

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR SERDAR BAYRAK

Offered to

Translational Oncology

Course Objective

It is aimed to explain tumor angiogenesis and tumor vascular structure, which play a critical role in the process of carcinogenesis.

Learning Outcomes of the Course Unit

1   Know the micro-environment's effect on tumoral formation stages.
2   To know the mechanism of angiogenesis step in the process of carcinogenesis.
3   Know tumor vascular structure.
4   Know angiogenic factors.
5   Gain knowledge about the role of anti-angiogenic therapies in cancer treatment.
6   Gain knowledge about hypoxic microenvironment and metastasis.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 The importance of the microenvironment in tumorigenesis Intravasation and Extravasation
2 Hypoxic tumor microenvironment and metabolic adaptation Tumor cells in circulation
3 Communication between different cells in the tumor microenvironmen The role and importance of angiogenesis in cancer treatment
4 Communication with growth factors and chemokines in the tumor microenvironment Anti-angiogenic treatment strategies
5 Endothelial structure, cell functions and vascular maturation Vascular normalization
6 Tumor vasculator structure
7 Types of tumor angiogenesis
8 Tumor angiogenesis and angiogenic factors
9 Extracellular matrix variability and basement membrane
10 Invasion and Migration

Recomended or Required Reading

1- KONUKOĞLU, D., & TURHAN, M. (2014). ANJIYOGENEZIN TEMEL MOLEKÜLER MEKANIZMALARI VE TÜMOR ANJIYOGENEZI. Cerrahpaşa Tıp Dergisi, 36(1), 42-48.
2- HAMUTOĞLU, R., & ÖNDER, O. (2017). Fizyolojik ve patolojik koşullarda anjiyogenezin rolü. Istanbul Bilim Üniversitesi Florence Nightingale Transplantasyon Dergisi, 2(2), 56-62.

Planned Learning Activities and Teaching Methods

Theoretical lectures, reinforcement and discussion of the subjects with in-class activities (presentations and assignments)

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PRF * 0.40 + FIN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PRF * 0.40 + FCGR*0.60


Further Notes About Assessment Methods

None

Assessment Criteria

Assessment with homework and PRESENTATION (Learning outcome 1,2 and 3)
Assessment with the exam (Learning outcome1,2,3 4,5 and 6)

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

serdar.bayrak@deu.edu.tr

Office Hours

Tuesday 14:00-15:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 3 45
Preparations before/after weekly lectures 15 2 30
Preparation for final exam 5 5 25
Preparing assignments 4 2 8
Preparing presentations 5 8 40
Final 1 2 2
TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.155
LO.255
LO.355
LO.4555
LO.5555
LO.655

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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