COURSE UNIT TITLE

: CANCER BIOLOGY AND GENETICS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 6013 CANCER BIOLOGY AND GENETICS ELECTIVE 2 0 0 6

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR GIZEM ÇALIBAŞI KOÇAL

Offered to

Canser Epidemiology Doctorate
Canser Epidemiology
Translational Oncology
Translational Oncology

Course Objective

The aim of this course, the emergence of cancer as a clinical process is the regaining of the basic information about the biological and genetic processes.

Learning Outcomes of the Course Unit

1   The basic mechanisms of cancer cell biology can be expressed with the main lines
2   Be able to know the basic processes in the genetics of cancer cells
3   Be able to know the differences of cancer cell biology and genetic processes than normal cells
4   Be able to discuss the function of oncogenes and tumor suppressor genes in carcinogenesis
5   Be able to Interpret the multistep process of cancer
6   Be able to critically evaluates the multistep carcinogenesis

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 DNA, Genes and Genome
2 Transcription and Translation: Gene Expression from DNA to Protein
3 DNA Replication and Cell Cycle
4 Oncogenes
5 Growth Factors, Signaling Pathways and Treatment Targets
6 Tumor Suppressor Genes and Growth Inhibition
7 Cell Death
8 Senescence, Telomeres, Cancer Stem Cells
9 DNA Damage, Repair and Genetic Instability
10 Epigenetic Regulation of Gene and Protein Expression
11 Tumor Angiogenesis
12 Invasion and metastasis: Epithelial-mesenchymal transition, Mesenchymal-epithelial transition, plasticity
13 Tumor microenvironment
14 Tumor immunity
15 Tumor metabolism

Recomended or Required Reading

The Biology of Cancer- 2nd edition. 2014. Robert A. Weinberg.
The Molecular Biology of Cancer: A Bridge from Bench to Bedside, 2nd Edition. 2013. Stella Pelengaris, Michael Khan.
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. PMID: 21376230.
Bakir B, Chiarella AM, Pitarresi JR, Rustgi AK. EMT, MET, Plasticity, and Tumor Metastasis. Trends Cell Biol. 2020 Oct;30(10):764-776. doi: 10.1016/j.tcb.2020.07.003. PMID: 32800658; PMCID: PMC7647095.
Klein CA. Cancer progression and the invisible phase of metastatic colonization. Nat Rev Cancer. 2020 Nov;20(11):681-694. doi: 10.1038/s41568-020-00300-6. PMID: 33024261.
Lyssiotis CA, Kimmelman AC. Metabolic Interactions in the Tumor Microenvironment. Trends Cell Biol. 2017 Nov;27(11):863-875. doi: 10.1016/j.tcb.2017.06.003. PMID: 28734735; PMCID: PMC5814137.
Elia I, Haigis MC. Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism. Nat Metab. 2021 Jan 4. doi: 10.1038/s42255-020-00317-z. PMID: 33398194.

Planned Learning Activities and Teaching Methods

Theoretical Lectures, the topics in-class activities (presentations and assignments) to consolidate and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PRF * 0.40 + FIN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PRF * 0.40 + FCGR*0.60


Further Notes About Assessment Methods

None

Assessment Criteria

The learner will clearly define outlined LO1,LO2, LO3 which will evaluate with exam.
The learner will recognize LO4, LO5, LO6, will evaluate with homework, prepared presentations by themselves and exam

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gizem.calibasi@deu.edu.tr ; 0 232 412 58 35

Office Hours

Monday 12.30-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 2 30
Preparations before/after weekly lectures 15 8 120
Final 1 1 1
TOTAL WORKLOAD (hours) 151

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.1555
LO.2555
LO.3555
LO.4555
LO.5555
LO.6555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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