COURSE UNIT TITLE

: TRANSLATIONAL RESEARCH METHODS I

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 6009 TRANSLATIONAL RESEARCH METHODS I ELECTIVE 1 2 0 10

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR GIZEM ÇALIBAŞI KOÇAL

Offered to

Translational Oncology
Translational Oncology

Course Objective

Translational perspective (from the bed to the lab from the lab to the bed) in cancer, Cancer Research Laboratory and R & D Laboratories Infrastructure, the sampling in cancer research, laboratory space of clinical trials, the diagnostic laboratory techniques, the laboratory techniques that provide for treatment response, tumor models (in vivo in vitro ex vivo, in silico, in toto) Biobanking in cancer research, imaging techniques in cancer research, cell culture (basic techniques, transformation, cellular modulations, culture (cell therapy, stem cells, etc., cytotoxicity, apoptosis, metastasis, invasion studies), treatment technologies will be discussed.

Learning Outcomes of the Course Unit

1   Capable of implementing advance molecular techniques for cancer research
2   Be able to know and apply methods for distinguishing individual differences
3   Be able to critically evaluates the published literature in the field of cancer research methods
4   Be able to recognize and comprehend the treatment technologies
5   Be able to recognize and comprehend the molecular diagnostics in cancer
6   Be able to establish a laboratory on cancer research

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Infrastructure of cancer research and R&D laboratories
2 Preparation stages in cancer research (sample preparation, purification, spectral techniques, immune techniques, electrophoresis, blotting, hybridization, microscopy)
3 Cell and organelle isolation in cancer research
4 Macromolecule isolations (DNA, RNA, Protein) in cancer research
5 PCR in cancer research
6 Next generation genetic analysis in cancer research
7 Transcript level expression analysis in cancer research
8 Protein-level expression analysis in cancer research
9 Epigenetic methods in cancer research
10 In silico methods in cancer research
11 Special staining techniques in cancer research
12 Special imaging techniques in cancer research
13 Cell culture in cancer research
14 Experimental animal studies in cancer research
15 Biobanking in cancer research

Recomended or Required Reading

Ruiz-Garcia, Erika, Astudillo-de la Vega, H. Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics. 2019 Springer.
Molecular Biology of the Cell, 6th Edition. Ed. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishers
Essential Cell Biology - 4th Edition Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter Garland Publishers
The Biology of Cancer, 2nd Edition, Robert A. Weinberg, Garland Publishers
Molecular Biology of the Gene, 7th edition, James Watson, Alexander Gann, Tania Baker, Michael Levine, Stephan Bell, Richard Losick, Stephan Harrison Pearson Cold Spring harbor Laboratory Press.
Principles of Molecular Diagnostics and Personalized Cancer Medicine, Dongfeng Tan, henry Lynch, Wolters Kluwer, Lippincott Williams&Wilkins.
The Handbook of Biomarkers, Kewal Jain, Humana Press
Translational and Experimental Clinical Research, Daniel Schuster, William Powers, Lippincott Williams&Wilkins.
Klinik Araştırmalar Kitabı 2014, Hamdi Akan, Hilal Ilbars, Nurşah Çetinkaya, Bilimsel Tıp Yayınevi
Designing Clinical Research 4th Edition, Steven R Cummings , Warren S Browner , Deborah G Grady , Thomas B Newman , Dr Stephen B Hulley, Lippincott Williams&Wilkins.
Journals
Clinical & translational oncology (1699-048X) in Springer
Translational oncology (1944-7124) in PubMed

Planned Learning Activities and Teaching Methods

Lectures, the topics with classroom activities (presentations and homework assignments) to consolidate and discussion

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PRF * 0.40 + FIN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PRF * 0.40 + FCGR*0.60


Further Notes About Assessment Methods

None

Assessment Criteria

The learner will clearly define outlined LO1, LO2, LO4, LO5 and which will evaluate with exam.
The learner will recognize LO3, LO6 will evaluate with homework, prepared presentations by themselves and exam.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

gizem.calibasi@deu.edu.tr ; 0 232 412 58 01

Office Hours

Friday 11:00-12:00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 3 45
Preparations before/after weekly lectures 15 13 195
Final 1 1 1
TOTAL WORKLOAD (hours) 241

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.155
LO.255
LO.355
LO.455
LO.555
LO.655

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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