COURSE UNIT TITLE

: GENE AND GENETIC APPLICATIONS IN MOLECULAR DIAGNOSIS

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
MOT 5024 GENE AND GENETIC APPLICATIONS IN MOLECULAR DIAGNOSIS ELECTIVE 3 0 0 5

Offered By

Molecular Medicine

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSOCIATE PROFESSOR YASEMIN SOYSAL

Offered to

Molecular Medicine
Molecular Medicine

Course Objective

Knowing the structure of the gene, which is one of the basic building blocks of genetics, and using this information in all fields related to genes are of priority. For this reason, firstly, it is aimed to understand the structure and functioning of the gene. Afterwards, it is aimed to give basic information about the principles of the tests used for diagnostic purposes, why, where and how to use them in studies to be carried out on the gene.

Learning Outcomes of the Course Unit

1   Learning the basic building blocks of the genome, DNA, replication, RNA, transcription and their related basic building blocks
2   Learning the structure of the gene, the structure of the genetic code and the regulation mechanisms of the gene
3   Understanding of genetic testing techniques used in clinical diagnostic laboratory applications
4   Gain knowledge about genetics tests used in clinical diagnosis
5   Understanding the fundamentals of genetics tests used in cancer and DNA based tissue typing

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Genome structure
2 Chromosome structure and research
3 Genetic code, Regulation
4 Cells and development
5 Genetic manipulations of cells and animals
6 Nucleic acid extraction methods, resolution and detection of nucleic acids
7 Analysis and characterization of nucleic acids and proteins, Nucleic acid amplification
8 Detection of gene mutations, Detection of DNA polymorphisms
9 DNA sequencing methods
10 Molecular detection of inherited diseases
11 Molecular basis of neoplasms
12 Quality assurance and quality control in the molecular Laboratory

Recomended or Required Reading

1. Molecular Diagnostics: Fundamentals, Methods and Clinical Applications. Lela Buckingham, 2nd Ed, 2012,F.A.Davis Company, Philadelphia, ISBN 13:978-0-8036-2677-5
2. Thompso&Thompson Genetics in Medicine, Elsevier Publishing
3. Renkli Genetik Atlası, Eberhard Passarge: Çevirenler: Güven Lüleci, Özgür Alper,Meral Sakızlı
4. Genetik Kavramlar, Clug and Cummings: Çeviren: Cihan Öner
5. Tıbbi Genetiğin Esasları, Tobias, Connor, Fergusson-Smith 6. Baskı,Çeviri Editörü: Uğur Özbek,Istanbul Tıp Kitabevi, 2014
6. Moleküler Biyolojide Kullanılan Yöntemler, Güler Temizkan, Nazlı Arda, Nobel Tıp Kitabevi, 2004, 2. Baskı
7. Molecular Biology of the Gene, 6th Ed. Watson, Baker, Bell, Gann, Levine, Losick, CSHL Press,

Planned Learning Activities and Teaching Methods

The course will be run in an integrated way-winding theory. The methods of learning will be interactive.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE MTE * 0.40 + FIN* 0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE MTE * 0.40 + RST* 0.60


Further Notes About Assessment Methods

None

Assessment Criteria

In order to be successful in the course, the average of the midterm (40% of the midterm) and final (60% of the final) grades must be at least 75 out of a hundred.

Language of Instruction

Turkish

Course Policies and Rules

The student is expected to read the resources before coming to class

Contact Details for the Lecturer(s)

Yasemin Soysal, PhD
AssociateProfessor
Dept. of Molecular Medicine,
Health Science Institute
Dokuz Eylul University
35340 Inciralti/Izmir Türkiye
Office: 0090 232 4126905

Office Hours

To be announced

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 12 3 36
Preparations before/after weekly lectures 12 2 24
Preparation for midterm exam 1 20 20
Preparation for final exam 1 25 25
Preparing presentations 1 20 20
Final 1 3 3
Midterm 1 3 3
TOTAL WORKLOAD (hours) 131

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13PO.14
LO.1555553433314
LO.2555553433214
LO.3555544344424
LO.4555435433434
LO.5555544445455

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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