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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS TOK 5011 GENERAL CONCEPTS IN TOXICOLOGY ELECTIVE 2 0 0 6

Offered By

Toxicology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR ŞULE KALKAN

Offered to

Toxicology CLINICAL DRUG RESEARCH

Course Objective

To learn cellular and molecular mechanism in toxicology, research methods, chemicals that cell injury, various poisonings, action mechanism of antidotes and antimetabolites, acute and chronic toxicity

Learning Outcomes of the Course Unit

1   1. To define the toxicology , to express the fields and history of toxicology 2   2. To learn the concepts of toxic dose and side effects, to distinguish dose-response relationship. 3   3. To evaluate the risk in toxicology 4   4. To apply the toxicity assessment methods in experimental animals, to relate to prediction of toxicity in human 5   5. To relate with toxicokinetics and toxicodynamics 6   6. To define the molecular mechanism in toxicology 7   7. To interpret the specific organ toxicity

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Definition of toxicology, fields and history 2 Concepts of toxic dose and side effect, , dose-response relationship 3 Evaluating the risk in toxicology 4 The toxicity assessment methods in experimental animals, to relate to prediction of toxicity in human 5 Toxicokinetic and toxicodynamic 6 Molecular mechanism in toxicology -1 Necrosis Apoptosis Oxidation-phosphorylation 7 Molecular mechanism in toxicology -2 Deterioration of gene expression Carcinogenesis mechanism (oncogenes in cell cycle, tumor suppressor genes) 8 Molecular mechanism in toxicology -3 DNA damage and mutations peroxisome proliferator 9 Organ Toxicity Metabolic changes Fluid and electrolyte balance disorders 10 Organ Toxicity-1 Cardiovascular toxicity 11 Organ Toxicity -2 Renal toxicity 12 Organ Toxicity-3 Central nervous system toxicity Immunotoxicology 13 Organ Toxicity-4 Respiratory system toxicity Gastrointestinal tract toxicity 14 Organ toksisitesi -5 Hematologic system toxicity Reprotoxicity 15 Final exam

Recomended or Required Reading

1. Curtis D. Claassen. Casarett & Doull's Toxicology: The Basic Science of Poisons, 7th edition, McGraw-Hill Company, USA, 2008. 2. Nelson L, Levin N, Howland MA, Hoffman R, Goldfrank L, Flomenbaum N (eds). Goldfrank s Toxicologic Emergencies, 9th edition, McGraw-Hill Company, USA, 2010.

Planned Learning Activities and Teaching Methods

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 FIN FINAL EXAM 2 FCG FINAL COURSE GRADE FIN*1 3 RST RESIT 4 FCGR FINAL COURSE GRADE (RESIT) RST*1

Further Notes About Assessment Methods

None

Assessment Criteria

To be announced.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

sule.kalkan@deu.edu.tr

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 2 28 Preparations before/after weekly lectures 14 8 112 Preparation for final exam 1 8 8 Final 1 2 2 TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 PO.9 PO.10 LO.1 3 3 3 3 3 3 3 3 3 3 LO.2 3 3 3 3 3 3 3 3 3 3 LO.3 3 3 3 3 3 3 3 3 3 3 LO.4 3 3 3 3 3 3 3 3 3 3 LO.5 3 3 3 3 3 3 3 3 3 3 LO.6 3 3 3 3 3 3 3 3 3 3 LO.7 3 3 3 3 3 3 3 3 3 3