COURSE UNIT TITLE

: DNA DAMAGE AND REPAIR MECHANISMS IN ONCOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 6102 DNA DAMAGE AND REPAIR MECHANISMS IN ONCOLOGY ELECTIVE 1 0 0 3

Offered By

Basic Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology
Basic Oncology

Course Objective

The aim of this course the acquisition of basic knowledge about DNA damage and related factors, mechanisms, DNA repair defects and DNA damage in development and treatment of in cancer.

Learning Outcomes of the Course Unit

1   Capable of identified the types of DNA damage and occured biological differences in development of DNA damage can express.
2   Be able to explain DNA repair mechanisms
3   Be able to recognize and understand the types of DNA repair and repair defect mechanisms and in the development of carsinogenesis
4   Be able to recognize and understand the DNA repair and repair defect mechanisms in therapy of cancer
5   Be able to know about molecular characterists of DNA repair defects mechanisms and konwledge in the clinical apperance in cancer

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 The introduction to DNA damage and mechanisms
2 Reactive radical damage in carsinogenesis and therapy of cancer
3 Radiation damage in carsinogenesis and therapy of cancer
4 DNA damage mechanism in carsinogenesis and therapy of cancer
5 DNA mistmach repair of DNA damage in carsinogenesis and therapy of cancer
6 Repair of DNA base excluision damage in carsinogenesis and therapy of cancer
7 DNA single strand defects in carsinogenesis and therapy of cancer
8 DNA double strand defects in carsinogenesis and therapy of cancer
9 Presentaions of homeworks
10 Repair of transcriptional active site defects in carsinogenesis and therapy of cancer
11 Postreplicational repair in carsinogenesis and therapy of cancer
12 Chromosomal stability in carsinogenesis and therapy of cancer
13 Methods of detection of DNA damage and repair defect mechanisms
14 DNA damage and repair defect mechanisms in the apperance clinical oncology
15 Presentations or reviews and evalution

Recomended or Required Reading

1. Principles and Practise of Oncology 7th edition. Vincent T De Vita 2005.
2. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
3. AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
4. Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
5. Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
6. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
7. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007

Planned Learning Activities and Teaching Methods

Theoretical and applied Lectures, giving a homework and preparing a projects.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 SEM SEMINAR
3 FCG FINAL COURSE GRADE ASG * 0.40 + SEM * 0.60


Further Notes About Assessment Methods

None

Assessment Criteria

The learner will clearly define outlined DNA damage and repair defect mechanisms in different types of cancers will evaluate with review prepared by themselves.
2. The learner will also enhance their knowledge about DNA damage and repair defect mechanisms which will be prepared by themselves.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

zekiye.altun@deu.edu.tr 0 232 4128204/5801

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparations before/after weekly lectures 15 1 15
Preparing assignments 1 15 15
Preparing presentations 1 30 30
TOTAL WORKLOAD (hours) 75

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.155
LO.255
LO.355
LO.455
LO.555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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