COURSE UNIT TITLE

: EXPERIMENTAL METHODS IN PHARMACOLOGY AND TOXICOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
FAR 6060 EXPERIMENTAL METHODS IN PHARMACOLOGY AND TOXICOLOGY ELECTIVE 1 2 0 6

Offered By

Pharmacology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR MUKADDES GÜMÜŞTEKIN

Offered to

Audiology
Laboratory Animal Science
Anatomy
Molecular Pathology
Exercise Physiology
Toxicology
Biochemistry
Biomechanics
Histology and Embryology
Medical Biology and Genetics
Biophysics
Physiology
Translational Oncology
Medical Parasitology
Microbiology
Pharmacology
Basic Neuroscience
Molecular Medicine
Translational Oncology
Molecular Medicine

Course Objective

Animal experimental methods and the care of experimental animals are essential parts of the course, including theoretical aspects as well as practical training. Experimental pharmacological methods are introduced, including operation techniques and in vitro experiments with excised tissues or organs. Within this course, a number of subjects are treated in some length. These subjects include organ bath studies, the Langendorff technique of isolated heart perfusion, pharmacokinetic studies, in vivo rat models of the measurement of blood pressure and ECG monitoring and etc.

Learning Outcomes of the Course Unit

1   be able to define the concepts and general information about the experimental methods in pharmacology
2   be able to compare in vivo and in vitro experimental methods
3   be able to understand the principles of experimental methods
4   be able to evaluate and identify the results of experimental studies
5   be able to know, predict and solve the problems which related of experimental studies

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 General principles for the care and use of animals for scientific purposes and animal housing and management
2 The routes of administration of drugs in experimental animals and dose calculation of drugs
3 General principles and techniques of anesthesia and sedation in laboratory animals.
4 The principles of preoperative management
5 Tissue Organ Bath Principles and techniques
6 Dose response studies and concentration-response relationships in isolated tissue preparations.
7 The principles of administration agonist or antagonist to organ bath, Assessment of agonist /antagonists effects in organ bath, Dose-response assessment, the concept of PD2 and PA2 and the calculation of EC50 and IC50
8 The principles of isolated heart preparation and experimental set-up, Asssesment of cardiac functions in isolated heart tissue by Langerdorf methods
9 Methods and techniques of carotid artery and jugular vein cannulation and endotracheal intubation
10 In vivo rat models of the measurement of blood pressure and ECG monitoring
11 Techiques of isolated aorta preparation
12 Techiques of isolated corpus cavernosum preparation
13 Techiques of isolated detrusor muscle preparation
14 The principles of cell culture and using in pharmacology and toxicology

Recomended or Required Reading

Textbook(s):
1- The Laboratory Rat, A Volume in The Laboratory Animal Pocket Reference Series. Ed. Mark A.Suckow, D.V.M., CRC Press (1998).
2- Manual of Microsurgery on the Laboratory Rats (1990).

Supplementary Book(s):
1- Manual for Laboratory Work in Mammalian Physiology (Fred D Amour).
2- Manual of Pharmacologic Calculations with Computer Programs (1987).
3- Experimental and Surgical Technique in the Rat-2. Ed (1992).
4- Deneysel Mikrocerrahi Temel Araştırma, Doku ve Organ Nakli Modelleri, Mehmet Bayramiçli.
5- Deney Hayvanları Kurs notları, Ege Üniversitesi (1999).
6- Deney Hayvanları, Prof. Dr. Nuri Yavru, Konya (1996).

Planned Learning Activities and Teaching Methods

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FCG FINAL COURSE GRADE PRF


Further Notes About Assessment Methods

Students are expected to make power point presentation related a subject from experimental methods in pharmacology and toxicology

Assessment Criteria

Students achievement will be measured by passing the final exam and making power point presentation related to a subject from course program

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

e-mail: gumustek@deu.edu.tr, telephone number: 4123906

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 14 1 14
Labratory 14 2 28
Preparations before/after weekly lectures 14 8 112
Preparation for final exam 0 0 0
Preparing presentations 0 0 0
Final 0 0 0
TOTAL WORKLOAD (hours) 154

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13
LO.154
LO.254333
LO.35
LO.4444
LO.5444

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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