COURSE UNIT TITLE

: INTRODUCTION TO LIQUID BIOPSIES

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 5051 INTRODUCTION TO LIQUID BIOPSIES ELECTIVE 1 0 0 3

Offered By

Basic Oncology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology

Course Objective

In the light of new developments in the field of oncology, it is possible to gain basic information about liquid biopsies and their areas of use and to continue the projects and scientific studies on the subject.

Learning Outcomes of the Course Unit

1   1. Can describe in general terms liquid biopsies and their role in cancer (information)
2   2. Recognizes and comprehends liquid biopsies and cancer in general terms.
3   3. Recognizes and comprehends the usage areas of liquid biopsies in cancer in general terms.
4   4. To be able to research and question studies on liquid biopsies and cancer.
5   5. To be able to search and question studies according to the areas of use in liquid biopsies and cancer.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction of Liquid biopsies Prof. Dr. Zekiye S. Altun
2 Sources of Liquid biopsies and contents Prof. Dr. Zekiye S. Altun
3 Extracellular vesicles and molecular features Prof. Dr. Zekiye S. Altun
4 Introduction to Free tumor DNA and Cancer Prof. Dr. Zekiye S. Altun
5 Introduction to Free tumor RNA and Cancer Prof. Dr. Zekiye S. Altun
6 Introduction to Free noncoding Tumor related RNA Prof. Dr. Zekiye S. Altun
7 Introduction to Liquid Biopsy analysis Prof. Dr. Zekiye S. Altun
8 Detection of ultrasensitive mutation with Sequencing in Liquid Biopsies Prof. Dr. Safiye Aktaş
9 An overview of single cell analyzes in liquid biopsies Prof. Dr. Zekiye S. Altun
10 Overview of PCR-based applications in liquid biopsy studies Prof. Dr. Zekiye S. Altun
11 Overview of Protein-based applications in liquid biopsy studies Prof. Dr. Zekiye S. Altun
12 Overview of transcriptomic analysis in liquid biopsy studies Prof. Dr. Zekiye S. Altun
13 An overview of data analysis and interpretation associated with liquid biopsy Prof. Dr. Zekiye S. Altun
14 An overview of the clinical use of liquid biopsies in cancer Prof. Dr. Zekiye S. Altun
15 Circulating tumor cells and molecular features Prof. Dr. Zekiye S. Altun

Recomended or Required Reading

Cancer: Principles and Practice of oncology, 12th Edition, DE vita ,
Medline, Embase, Web of Science ve diğer akademik tarama ortamları
Altun ZS. Rna dan Ve Proteoformlara Temel Araştirma Yöntemleri. Klinisyenler Için Temel Onkoloji. 1. Baskı. Ankara: Türkiye Klinikleri; 2021. p.102- 5. 2021 e-Isbn: 978-625-401-395-9.Alix-Panabieres, C., and Pantel, K. (2014). Technologies for detection of circulating tumor cells: facts and vision. Lab on a chip 14, 57-62.
Ashworth, T.R. (1869). A case of cancer in which cells similar to those in the tumours were seen in the blood after death. Australian Medical Journal, 146 -147.
Banys, M., Neubauer, H., Ruckhaeberle, E., and Fehm, T. (2014). Expression of Stem Cell and Epithelial-Mesenchymal Transition Markers in Circulating Tumor Cells of Breast Cancer Patients. BioMed research international.
Butler, T.P., and Gullino, P.M. (1975). Quantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer research 35, 512-516.
Coumans, F.A., Siesling, S., and Terstappen, L.W. (2013). Detection of cancer before distant metastasis. BMC cancer

Planned Learning Activities and Teaching Methods

Theoretical lectures, reinforcement and discussion of the subjects with in-class activities, scientific literature, presentations and assignments.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 PAR PARTICIPATION
3 FCG FINAL COURSE GRADE ODV * 0.50 + DKL * 0.50


Further Notes About Assessment Methods

None

Assessment Criteria

Graduate students should actively participate in lectures and literature vs. discussions about liquid biopsy. Students should evaluate their knowledge about the subject as an exam about liquid biopsies and their usage area. He/she should prepare a homework presentation that includes current changes with the subject.

Language of Instruction

Turkish

Course Policies and Rules

It will be announced.

Contact Details for the Lecturer(s)

zekiye.altun@deu.edu.tr, Tel: +90(232)4128204

Office Hours

on Tuesday hours: 13.00-13.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparations before/after weekly lectures 15 2 30
Preparation for midterm exam 1 15 15
Preparing assignments 1 10 10
Preparing presentations 1 4 4
Midterm 1 1 1
TOTAL WORKLOAD (hours) 75

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10
LO.15445555
LO.24545554
LO.35554555
LO.455554
LO.555554

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

Copyright 2015 DEÜ. BİD

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