COURSE UNIT TITLE

: INTRODUCTION TO MOLECULAR MECHANISMS OF ANTICANCER THERAPIES

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
ONK 5047 INTRODUCTION TO MOLECULAR MECHANISMS OF ANTICANCER THERAPIES ELECTIVE 1 0 0 2

Offered By

Basic Oncology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR ZEKIYE SULTAN ALTUN

Offered to

Basic Oncology
Basic Oncology

Course Objective

The aim of this course is to understand the factors which contribute to cancer therapy, molecular mechanisms of cancer treatments and cancer therapy.

Learning Outcomes of the Course Unit

1   Capable of understanding the molecular mechanisms of anticancer agents.
2   Be able to explain relationship anticancer agents and their role in treatment of associated cancer types.
3   Be able to know and learn molecular effects of therapeutic agents against lung, breast, colorectal cancer and urogenital cancers and neuroblastoma.
4   Be able to know and learn possible targets of new therapeutic agents.
5   Be able to understand the molecular characteristics and clinical usage of anticancer agents.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Anticancer treatment methods
2 Alkylating Agents and molecular mechanisms
3 Cisplatin and Its analogues and molecular mechanisms
4 Antimetabolits and molecular mechanisms
5 Topoisomerase inhibitors and molecular mechanisms
6 Microtubul inhibitors and molecular mechanisms
7 Monoclonal antibodies and molecular mechanisms
8 HDAC inhibitors and molecular mechanisms
9 Presentations of homeworks
10 Molecular approach to lung cancer therapy
11 Molecular approach to childhood cancer treatments
12 Molecular approach to breast cancer therapy
13 Molecular approach to colorectal cancer therapy
14 Molecular approach to urogenital cancer therapy
15 Project presentaions

Recomended or Required Reading

1. Principles and Practise of Oncology 7th edition. Vincent T De Vita 2005.
2. Diagnostic Approach to Clinical Oncology Mario W. Fiorentino PICCIN 1999
3. Molecular Biology in Cancer Medicine. Razelle Kurzrock, Moshe Talpaz, Martin Dunitz 1995.
4. AJCC Cancer Staging Handbook.Irvin D. Fleming. Lippincott Willams & Wilkins 1998
5. Manual of Clinical Oncology. D.K. Hossfeld, C.D. Sherman, R.R. Love, F.X. Bosch Springer- Verlag, 1990 Fith Edition.
6. Pathologic Basis of Disease. Vinay Kumar, Abul K. Abbas, Nelson Fausto, Elsevier Saunderss, 2005 Seventh Edition
7. Molecular Mechanism of Cancer. Georg F. Weber, Springer 2007
8. The Biology of Cancer Robert A. Weinberg, Gariand Science 2007

Planned Learning Activities and Teaching Methods

Theoretical Lectures, Giving a homework, Working for exams, Reading practices

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 SEM SEMINAR
3 FCG FINAL COURSE GRADE ASG * 0.40 + SEM * 0.60


Further Notes About Assessment Methods

None

Assessment Criteria

Learning outcomes will be assessed with preparation of review related to discussing the new therapeutic agents can target special types of cancers and molecular mechanisms in special cancers such as melanoma, ovarian cancer, renal cell cancer and neuroblastoma.
The homework on the topic of Imatinib mesylate, Bevacizumab, Rapamycin and Borteozomib molecular mechanisms of action of such agents and their usage in different kinds of cancer treatment will help in evaluating the learner understood the topics or not.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

zekiye.altun@deu.edu.tr 0 232 4128204/5801

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 1 15
Preparations before/after weekly lectures 15 1 15
Preparing presentations 1 10 10
Project Preparation 1 10 10
TOTAL WORKLOAD (hours) 50

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10
LO.155
LO.255
LO.355
LO.455
LO.555

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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